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| http://purl.uniprot.org/citations/22763120 | http://www.w3.org/2000/01/rdf-schema#comment | "AMP-dependent kinase (AMPK) and GLUT1-mediated sugar transport in blood-brain barrier endothelial cells are activated during acute cellular metabolic stress. Using murine brain microvasculature endothelium bEnd.3 cells, we show that AMPK phosphorylation and stimulation of 3-O-methylglucose transport by the AMPK agonist AICAR are inhibited in a dose-dependent manner by the AMPK antagonist Compound C. AMPK α1- or AMPK α2-knockdown by RNA interference or AMPK inhibition by Compound C reduces AMPK phosphorylation and 3-O-methylglucose transport stimulation induced by cellular glucose-depletion, by potassium cyanide (KCN), or by carbonyl cyanide-p-trifluoromethoxy-phenylhydrazone (FCCP). Cell surface biotinylation studies reveal that plasma membrane GLUT1 levels are increased two-to threefold by cellular glucose depletion, AICAR or KCN treatment, and that these increases are prevented by Compound C and by AMPK α1- or α2-knockdown. These results support the hypothesis that AMPK activation in blood-brain barrier-derived endothelial cells directs the trafficking of GLUT1 intracellular pools to the plasma membrane, thereby increasing endothelial sugar transport capacity."xsd:string |
| http://purl.uniprot.org/citations/22763120 | http://purl.org/dc/terms/identifier | "doi:10.1152/ajpcell.00437.2011"xsd:string |
| http://purl.uniprot.org/citations/22763120 | http://purl.uniprot.org/core/author | "Carruthers A."xsd:string |
| http://purl.uniprot.org/citations/22763120 | http://purl.uniprot.org/core/author | "Cura A.J."xsd:string |
| http://purl.uniprot.org/citations/22763120 | http://purl.uniprot.org/core/date | "2012"xsd:gYear |
| http://purl.uniprot.org/citations/22763120 | http://purl.uniprot.org/core/name | "Am J Physiol Cell Physiol"xsd:string |
| http://purl.uniprot.org/citations/22763120 | http://purl.uniprot.org/core/pages | "C806-14"xsd:string |
| http://purl.uniprot.org/citations/22763120 | http://purl.uniprot.org/core/title | "AMP kinase regulation of sugar transport in brain capillary endothelial cells during acute metabolic stress."xsd:string |
| http://purl.uniprot.org/citations/22763120 | http://purl.uniprot.org/core/volume | "303"xsd:string |
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