| http://purl.uniprot.org/citations/22764245 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/22764245 | http://www.w3.org/2000/01/rdf-schema#comment | "It is generally accepted that presynaptic transmitter release is mainly regulated by subtypes of neuronal high-voltage-activated Ca(2+) channels. Here for the first time, we examined the role of T-type Ca(2+) channels (T-channels) in synaptic transmission in the dorsal horn (DH) of the spinal cord using patch-clamp recordings from acute spinal cord preparations from both rat and mouse. We found that selective pharmacological antagonism of T-channels inhibited spontaneous synaptic release of glutamate in superficial laminae I-II of the DH, while GABA release was spared. We found similar effect in identified nociceptive projection neurons of lamina I of the DH, but not in inhibitory DH interneurons. In comparison, antagonism of T-channels did not affect excitatory transmission in deeper non-nociceptive DH laminae. Furthermore, we used isoform-specific agents, knock-out mice and immunohistochemistry to specifically implicate presynaptic Ca(V)3.2 channels. We also used an animal model of painful diabetic neuropathy to demonstrate that blocking T-channels in superficial DH neurons suppressed spontaneous excitatory synaptic transmission in diabetic rats in greater degree than in healthy age-matched animals. These studies provide previously unknown information regarding the role of presynaptic T-channels in nociceptive signaling in the spinal cord."xsd:string |
| http://purl.uniprot.org/citations/22764245 | http://purl.org/dc/terms/identifier | "doi:10.1523/jneurosci.0068-12.2012"xsd:string |
| http://purl.uniprot.org/citations/22764245 | http://purl.uniprot.org/core/author | "Uebele V.N."xsd:string |
| http://purl.uniprot.org/citations/22764245 | http://purl.uniprot.org/core/author | "Renger J.J."xsd:string |
| http://purl.uniprot.org/citations/22764245 | http://purl.uniprot.org/core/author | "Todorovic S.M."xsd:string |
| http://purl.uniprot.org/citations/22764245 | http://purl.uniprot.org/core/author | "Jacus M.O."xsd:string |
| http://purl.uniprot.org/citations/22764245 | http://purl.uniprot.org/core/date | "2012"xsd:gYear |
| http://purl.uniprot.org/citations/22764245 | http://purl.uniprot.org/core/name | "J Neurosci"xsd:string |
| http://purl.uniprot.org/citations/22764245 | http://purl.uniprot.org/core/pages | "9374-9382"xsd:string |
| http://purl.uniprot.org/citations/22764245 | http://purl.uniprot.org/core/title | "Presynaptic Cav3.2 channels regulate excitatory neurotransmission in nociceptive dorsal horn neurons."xsd:string |
| http://purl.uniprot.org/citations/22764245 | http://purl.uniprot.org/core/volume | "32"xsd:string |
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