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http://purl.uniprot.org/citations/22764640http://www.w3.org/1999/02/22-rdf-syntax-ns#typehttp://purl.uniprot.org/core/Journal_Citation
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Objective

To ascertain the association of -3826 A/G polymorphism with blood pressure and different obesity markers.

Design and subjects

A total of 96 adult participants (49 males, 47 females) were studied. Anthropometric measurements and blood pressure were taken using standardized techniques. Obesity indices of body mass index (BMI), waist hip ratio (WHR), waist height ratio (WHtR) and grand mean thickness (GMT) were computed. For genetic analysis, DNA was extracted from 50 microL blood.

Results

A statistically significant difference between various genotypes of UCP1 and BMI, GMT, systolic blood pressure, diastolic blood pressure was found among females. In GGC homozygote, blood pressure showed positive and significant association with fat percentage and GMT (P < .001). Waist circumference, WHR, WHtR and BMI also showed positive association with blood pressure in heterozygous and homozygous GG form.

Conclusion

This study links the GG homozygous form of UCP1 with obesity and blood pressure among females only."xsd:string
http://purl.uniprot.org/citations/22764640http://purl.uniprot.org/core/author"Kapoor S."xsd:string
http://purl.uniprot.org/citations/22764640http://purl.uniprot.org/core/author"Chaturvedi M.M."xsd:string
http://purl.uniprot.org/citations/22764640http://purl.uniprot.org/core/author"Rai U."xsd:string
http://purl.uniprot.org/citations/22764640http://purl.uniprot.org/core/author"Dhall M."xsd:string
http://purl.uniprot.org/citations/22764640http://purl.uniprot.org/core/date"2012"xsd:gYear
http://purl.uniprot.org/citations/22764640http://purl.uniprot.org/core/name"Ethn Dis"xsd:string
http://purl.uniprot.org/citations/22764640http://purl.uniprot.org/core/pages"181-184"xsd:string
http://purl.uniprot.org/citations/22764640http://purl.uniprot.org/core/title"Sex-dependent effects of the UCP1 -3826 A/G polymorphism on obesity and blood pressure."xsd:string
http://purl.uniprot.org/citations/22764640http://purl.uniprot.org/core/volume"22"xsd:string
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http://purl.uniprot.org/citations/22764640http://xmlns.com/foaf/0.1/primaryTopicOfhttps://pubmed.ncbi.nlm.nih.gov/22764640
http://purl.uniprot.org/uniprot/#_P25874-mappedCitation-22764640http://www.w3.org/1999/02/22-rdf-syntax-ns#objecthttp://purl.uniprot.org/citations/22764640
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http://purl.uniprot.org/uniprot/P25874http://purl.uniprot.org/core/mappedCitationhttp://purl.uniprot.org/citations/22764640
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