| http://purl.uniprot.org/citations/22766233 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/22766233 | http://www.w3.org/2000/01/rdf-schema#comment | "Abelson interactor protein 1 (Abi-1) localizes to postsynaptic densities (PSDs) of excitatory synapses and was shown to be transported from the PSD to the nucleus and back depending upon synaptic activation. We employed a yeast-two-hybrid screen to search for putative transport molecules. We found Kif26B a member of the Kif family of transport proteins that has not been characterized in the central nervous system as a direct interaction partner of Abi-1. We delineated a proline-rich motif within the cargo-binding domain of Kif26B to be responsible for this protein-protein interaction. Kif26B was able to recruit Abi-1 to the microtubule network and we found that the expression of Kif26B is responsible for the localization of Abi-1 to PSDs in maturing neurons. Taken together we report that Abi-1 is a cargo of Kif26B in primary hippocampal neurons, pointing to a role of this transport molecule in the movement of Abi-1 between different cell compartments. Additionally, we provide the first detailed investigation of Kif26B and its cargo molecules in neuronal cells."xsd:string |
| http://purl.uniprot.org/citations/22766233 | http://purl.org/dc/terms/identifier | "doi:10.1016/j.neuroscience.2012.06.055"xsd:string |
| http://purl.uniprot.org/citations/22766233 | http://purl.uniprot.org/core/author | "Schmidt T."xsd:string |
| http://purl.uniprot.org/citations/22766233 | http://purl.uniprot.org/core/author | "Boeckers T.M."xsd:string |
| http://purl.uniprot.org/citations/22766233 | http://purl.uniprot.org/core/author | "Liebau S."xsd:string |
| http://purl.uniprot.org/citations/22766233 | http://purl.uniprot.org/core/author | "Proepper C."xsd:string |
| http://purl.uniprot.org/citations/22766233 | http://purl.uniprot.org/core/author | "Heinrich J."xsd:string |
| http://purl.uniprot.org/citations/22766233 | http://purl.uniprot.org/core/author | "Linta L."xsd:string |
| http://purl.uniprot.org/citations/22766233 | http://purl.uniprot.org/core/date | "2012"xsd:gYear |
| http://purl.uniprot.org/citations/22766233 | http://purl.uniprot.org/core/name | "Neuroscience"xsd:string |
| http://purl.uniprot.org/citations/22766233 | http://purl.uniprot.org/core/pages | "86-95"xsd:string |
| http://purl.uniprot.org/citations/22766233 | http://purl.uniprot.org/core/title | "The postsynaptic density protein Abelson interactor protein 1 interacts with the motor protein Kinesin family member 26B in hippocampal neurons."xsd:string |
| http://purl.uniprot.org/citations/22766233 | http://purl.uniprot.org/core/volume | "221"xsd:string |
| http://purl.uniprot.org/citations/22766233 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/22766233 |
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