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| http://purl.uniprot.org/citations/22773306 | http://www.w3.org/2000/01/rdf-schema#comment | "The Drosophila melanogaster orthologue of the c-Cbl proto-oncogene acts to downregulate signalling from receptor tyrosine kinases by enhancing endocytosis of activated receptors. Expression of an analogue of the C-terminally truncated v-Cbl oncogene, Dv-cbl, in the developing Drosophila eye conversely leads to excess signalling and disruption to the well-ordered adult compound eye. Co-expression of activated Ras with Dv-cbl leads to a severe disruption of eye development. We have used a transposon-based inducible expression system to screen for molecules that can suppress the Dv-cbl phenotype and have identified an allele that upregulates the A-kinase anchoring protein, Akap200. Overexpression of Akap200 not only suppresses the phenotype caused by Dv-cbl expression, but also the severe disruption to eye development caused by the combined expression of Dv-cbl and activated Ras. Akap200 is also endogenously expressed in the developing Drosophila eye at a level that modulates the effects of excessive signalling caused by expression of Dv-cbl."xsd:string |
| http://purl.uniprot.org/citations/22773306 | http://purl.org/dc/terms/identifier | "doi:10.1007/s11010-012-1376-x"xsd:string |
| http://purl.uniprot.org/citations/22773306 | http://purl.uniprot.org/core/author | "Hime G.R."xsd:string |
| http://purl.uniprot.org/citations/22773306 | http://purl.uniprot.org/core/author | "Robertson H."xsd:string |
| http://purl.uniprot.org/citations/22773306 | http://purl.uniprot.org/core/author | "Siddall N.A."xsd:string |
| http://purl.uniprot.org/citations/22773306 | http://purl.uniprot.org/core/author | "Sannang R.T."xsd:string |
| http://purl.uniprot.org/citations/22773306 | http://purl.uniprot.org/core/date | "2012"xsd:gYear |
| http://purl.uniprot.org/citations/22773306 | http://purl.uniprot.org/core/name | "Mol Cell Biochem"xsd:string |
| http://purl.uniprot.org/citations/22773306 | http://purl.uniprot.org/core/pages | "135-145"xsd:string |
| http://purl.uniprot.org/citations/22773306 | http://purl.uniprot.org/core/title | "Akap200 suppresses the effects of Dv-cbl expression in the Drosophila eye."xsd:string |
| http://purl.uniprot.org/citations/22773306 | http://purl.uniprot.org/core/volume | "369"xsd:string |
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