| http://purl.uniprot.org/citations/22773666 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/22773666 | http://www.w3.org/2000/01/rdf-schema#comment | "Environmental factors such as diets rich in saturated fats contribute to dysfunction and death of pancreatic β-cells in diabetes. Endoplasmic reticulum (ER) stress is elicited in β-cells by saturated fatty acids. Here we show that palmitate-induced β-cell apoptosis is mediated by the intrinsic mitochondrial pathway. By microarray analysis, we identified a palmitate-triggered ER stress gene expression signature and the induction of the BH3-only proteins death protein 5 (DP5) and p53-upregulated modulator of apoptosis (PUMA). Knockdown of either protein reduced cytochrome c release, caspase-3 activation, and apoptosis in rat and human β-cells. DP5 induction depends on inositol-requiring enzyme 1 (IRE1)-dependent c-Jun NH₂-terminal kinase and PKR-like ER kinase (PERK)-induced activating transcription factor (ATF3) binding to its promoter. PUMA expression is also PERK/ATF3-dependent, through tribbles 3 (TRB3)-regulated AKT inhibition and FoxO3a activation. DP5(-/-) mice are protected from high fat diet-induced loss of glucose tolerance and have twofold greater pancreatic β-cell mass. This study elucidates the crosstalk between lipotoxic ER stress and the mitochondrial pathway of apoptosis that causes β-cell death in diabetes."xsd:string |
| http://purl.uniprot.org/citations/22773666 | http://purl.org/dc/terms/identifier | "doi:10.2337/db12-0123"xsd:string |
| http://purl.uniprot.org/citations/22773666 | http://purl.uniprot.org/core/author | "Fukaya M."xsd:string |
| http://purl.uniprot.org/citations/22773666 | http://purl.uniprot.org/core/author | "Cunha D.A."xsd:string |
| http://purl.uniprot.org/citations/22773666 | http://purl.uniprot.org/core/author | "Marchetti P."xsd:string |
| http://purl.uniprot.org/citations/22773666 | http://purl.uniprot.org/core/author | "Marselli L."xsd:string |
| http://purl.uniprot.org/citations/22773666 | http://purl.uniprot.org/core/author | "Harding H.P."xsd:string |
| http://purl.uniprot.org/citations/22773666 | http://purl.uniprot.org/core/author | "Ron D."xsd:string |
| http://purl.uniprot.org/citations/22773666 | http://purl.uniprot.org/core/author | "Mathieu C."xsd:string |
| http://purl.uniprot.org/citations/22773666 | http://purl.uniprot.org/core/author | "Cnop M."xsd:string |
| http://purl.uniprot.org/citations/22773666 | http://purl.uniprot.org/core/author | "Igoillo-Esteve M."xsd:string |
| http://purl.uniprot.org/citations/22773666 | http://purl.uniprot.org/core/author | "Eizirik D.L."xsd:string |
| http://purl.uniprot.org/citations/22773666 | http://purl.uniprot.org/core/author | "Vanderwinden J.M."xsd:string |
| http://purl.uniprot.org/citations/22773666 | http://purl.uniprot.org/core/author | "Gysemans C."xsd:string |
| http://purl.uniprot.org/citations/22773666 | http://purl.uniprot.org/core/author | "Germano C.M."xsd:string |
| http://purl.uniprot.org/citations/22773666 | http://purl.uniprot.org/core/author | "Marhfour I."xsd:string |
| http://purl.uniprot.org/citations/22773666 | http://purl.uniprot.org/core/author | "Naamane N."xsd:string |
| http://purl.uniprot.org/citations/22773666 | http://purl.uniprot.org/core/author | "Gurzov E.N."xsd:string |
| http://purl.uniprot.org/citations/22773666 | http://purl.uniprot.org/core/date | "2012"xsd:gYear |
| http://purl.uniprot.org/citations/22773666 | http://purl.uniprot.org/core/name | "Diabetes"xsd:string |
| http://purl.uniprot.org/citations/22773666 | http://purl.uniprot.org/core/pages | "2763-2775"xsd:string |
| http://purl.uniprot.org/citations/22773666 | http://purl.uniprot.org/core/title | "Death protein 5 and p53-upregulated modulator of apoptosis mediate the endoplasmic reticulum stress-mitochondrial dialog triggering lipotoxic rodent and human beta-cell apoptosis."xsd:string |
| http://purl.uniprot.org/citations/22773666 | http://purl.uniprot.org/core/volume | "61"xsd:string |
| http://purl.uniprot.org/citations/22773666 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/22773666 |