| http://purl.uniprot.org/citations/22773952 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/22773952 | http://www.w3.org/2000/01/rdf-schema#comment | "A complex of stomatin-family proteins and acid-sensing (proton-gated) ion channel (ASIC) family members participate in sensory transduction in invertebrates and vertebrates. Here, we have examined the role of the stomatin-family protein stomatin-like protein-3 (STOML3) in this process. We demonstrate that STOML3 interacts with stomatin and ASIC subunits and that this occurs in a highly mobile vesicle pool in dorsal root ganglia (DRG) neurons and Chinese hamster ovary cells. We identify a hydrophobic region in the N-terminus of STOML3 that is required for vesicular localization of STOML3 and regulates physical and functional interaction with ASICs. We further characterize STOML3-containing vesicles in DRG neurons and show that they are Rab11-positive, but not part of the early-endosomal, lysosomal or Rab14-dependent biosynthetic compartment. Moreover, uncoupling of vesicles from microtubules leads to incorporation of STOML3 into the plasma membrane and increased acid-gated currents. Thus, STOML3 defines a vesicle pool in which it associates with molecules that have critical roles in sensory transduction. We suggest that the molecular features of this vesicular pool may be characteristic of a 'transducosome' in sensory neurons."xsd:string |
| http://purl.uniprot.org/citations/22773952 | http://purl.org/dc/terms/identifier | "doi:10.1098/rsob.120096"xsd:string |
| http://purl.uniprot.org/citations/22773952 | http://purl.uniprot.org/core/author | "Kozlenkov A."xsd:string |
| http://purl.uniprot.org/citations/22773952 | http://purl.uniprot.org/core/author | "Lapatsina L."xsd:string |
| http://purl.uniprot.org/citations/22773952 | http://purl.uniprot.org/core/author | "Lewin G.R."xsd:string |
| http://purl.uniprot.org/citations/22773952 | http://purl.uniprot.org/core/author | "Poole K."xsd:string |
| http://purl.uniprot.org/citations/22773952 | http://purl.uniprot.org/core/author | "Smith E.S."xsd:string |
| http://purl.uniprot.org/citations/22773952 | http://purl.uniprot.org/core/author | "Heppenstall P.A."xsd:string |
| http://purl.uniprot.org/citations/22773952 | http://purl.uniprot.org/core/author | "Bilbao D."xsd:string |
| http://purl.uniprot.org/citations/22773952 | http://purl.uniprot.org/core/author | "Jira J.A."xsd:string |
| http://purl.uniprot.org/citations/22773952 | http://purl.uniprot.org/core/date | "2012"xsd:gYear |
| http://purl.uniprot.org/citations/22773952 | http://purl.uniprot.org/core/name | "Open Biol"xsd:string |
| http://purl.uniprot.org/citations/22773952 | http://purl.uniprot.org/core/pages | "120096"xsd:string |
| http://purl.uniprot.org/citations/22773952 | http://purl.uniprot.org/core/title | "Regulation of ASIC channels by a stomatin/STOML3 complex located in a mobile vesicle pool in sensory neurons."xsd:string |
| http://purl.uniprot.org/citations/22773952 | http://purl.uniprot.org/core/volume | "2"xsd:string |
| http://purl.uniprot.org/citations/22773952 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/22773952 |
| http://purl.uniprot.org/citations/22773952 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/22773952 |
| http://purl.uniprot.org/uniprot/#_B2RS16-mappedCitation-22773952 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/22773952 |
| http://purl.uniprot.org/uniprot/#_I6L9A4-mappedCitation-22773952 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/22773952 |
| http://purl.uniprot.org/uniprot/#_P27105-mappedCitation-22773952 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/22773952 |
| http://purl.uniprot.org/uniprot/#_Q16515-mappedCitation-22773952 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/22773952 |
| http://purl.uniprot.org/uniprot/#_Q6PE84-mappedCitation-22773952 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/22773952 |
| http://purl.uniprot.org/uniprot/#_P78348-mappedCitation-22773952 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/22773952 |
| http://purl.uniprot.org/uniprot/#_P97811-mappedCitation-22773952 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/22773952 |