| http://purl.uniprot.org/citations/22774996 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/22774996 | http://www.w3.org/2000/01/rdf-schema#comment | "Urocortin 3 (also known as stresscopin) is an endogenous ligand for the corticotropin-releasing factor receptor 2 (CRF(2)). Despite predominant G(s) coupling of CRF(2), promiscuous coupling with other G proteins has been also associated with the activation of this receptor. As urocortin 3 has been involved in central cardiovascular regulation at hypothalamic and medullary sites, we examined its cellular effects on cardiac vagal neurons of nucleus ambiguus, a key area for the autonomic control of heart rate. Urocortin 3 (1 nM-1000 nM) induced a concentration-dependent increase in cytosolic Ca(2+) concentration that was blocked by the CRF(2) antagonist K41498. In the case of two consecutive treatments with urocortin 3, the second urocortin 3-induced Ca(2+) response was reduced, indicating receptor desensitization. The effect of urocortin 3 was abolished by pre-treatment with pertussis toxin and by inhibition of phospolipase C with U-73122. Urocortin 3 activated Ca(2+) influx via voltage-gated P/Q-type channels as well as Ca(2+) release from endoplasmic reticulum. Urocortin 3 promoted Ca(2+) release via inositol 1,4,5 trisphosphate receptors, but not ryanodine receptors. Our results indicate a novel Ca(2+) -mobilizing effect of urocortin 3 in vagal pre-ganglionic neurons of nucleus ambiguus, providing a cellular mechanism for a previously reported role for this peptide in parasympathetic cardiac regulation."xsd:string |
| http://purl.uniprot.org/citations/22774996 | http://purl.org/dc/terms/identifier | "doi:10.1111/j.1471-4159.2012.07869.x"xsd:string |
| http://purl.uniprot.org/citations/22774996 | http://purl.uniprot.org/core/author | "Brailoiu E."xsd:string |
| http://purl.uniprot.org/citations/22774996 | http://purl.uniprot.org/core/author | "Brailoiu G.C."xsd:string |
| http://purl.uniprot.org/citations/22774996 | http://purl.uniprot.org/core/author | "Deliu E."xsd:string |
| http://purl.uniprot.org/citations/22774996 | http://purl.uniprot.org/core/author | "Tica A.A."xsd:string |
| http://purl.uniprot.org/citations/22774996 | http://purl.uniprot.org/core/author | "Chitravanshi V.C."xsd:string |
| http://purl.uniprot.org/citations/22774996 | http://purl.uniprot.org/core/date | "2012"xsd:gYear |
| http://purl.uniprot.org/citations/22774996 | http://purl.uniprot.org/core/name | "J Neurochem"xsd:string |
| http://purl.uniprot.org/citations/22774996 | http://purl.uniprot.org/core/pages | "1129-1136"xsd:string |
| http://purl.uniprot.org/citations/22774996 | http://purl.uniprot.org/core/title | "Urocortin 3 elevates cytosolic calcium in nucleus ambiguus neurons."xsd:string |
| http://purl.uniprot.org/citations/22774996 | http://purl.uniprot.org/core/volume | "122"xsd:string |
| http://purl.uniprot.org/citations/22774996 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/22774996 |
| http://purl.uniprot.org/citations/22774996 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/22774996 |
| http://purl.uniprot.org/uniprot/#_A0A9K3Y7D4-mappedCitation-22774996 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/22774996 |
| http://purl.uniprot.org/uniprot/#_A1YKY5-mappedCitation-22774996 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/22774996 |
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| http://purl.uniprot.org/uniprot/A1YKY5 | http://purl.uniprot.org/core/mappedCitation | http://purl.uniprot.org/citations/22774996 |