| http://purl.uniprot.org/citations/22778137 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/22778137 | http://www.w3.org/2000/01/rdf-schema#comment | "Peyer's patches consist of domains of specialized intestinal epithelium overlying gut-associated lymphoid tissue (GALT). Luminal antigens reach the GALT by translocation through epithelial gatekeeper cells, the so-called M cells. We recently demonstrated that all epithelial cells required for the digestive functions of the intestine are generated from Lgr5-expressing stem cells. Here, we show that M cells also derive from these crypt-based Lgr5 stem cells. The Ets family transcription factor SpiB, known to control effector functions of bone marrow-derived immune cells, is specifically expressed in M cells. In SpiB(-/-) mice, M cells are entirely absent, which occurs in a cell-autonomous fashion. It has been shown that Tnfsf11 (RankL) can induce M cell development in vivo. We show that in intestinal organoid ("minigut") cultures, stimulation with RankL induces SpiB expression within 24 h and expression of other M cell markers subsequently. We conclude that RankL-induced expression of SpiB is essential for Lgr5 stem cell-derived epithelial precursors to develop into M cells."xsd:string |
| http://purl.uniprot.org/citations/22778137 | http://purl.org/dc/terms/identifier | "doi:10.1128/mcb.00434-12"xsd:string |
| http://purl.uniprot.org/citations/22778137 | http://purl.uniprot.org/core/author | "Schneeberger K."xsd:string |
| http://purl.uniprot.org/citations/22778137 | http://purl.uniprot.org/core/author | "Barker N."xsd:string |
| http://purl.uniprot.org/citations/22778137 | http://purl.uniprot.org/core/author | "Peters P.J."xsd:string |
| http://purl.uniprot.org/citations/22778137 | http://purl.uniprot.org/core/author | "Clevers H."xsd:string |
| http://purl.uniprot.org/citations/22778137 | http://purl.uniprot.org/core/author | "Kujala P."xsd:string |
| http://purl.uniprot.org/citations/22778137 | http://purl.uniprot.org/core/author | "Middendorp S."xsd:string |
| http://purl.uniprot.org/citations/22778137 | http://purl.uniprot.org/core/author | "Li V.S."xsd:string |
| http://purl.uniprot.org/citations/22778137 | http://purl.uniprot.org/core/author | "Nieuwenhuis E."xsd:string |
| http://purl.uniprot.org/citations/22778137 | http://purl.uniprot.org/core/author | "de Lau W."xsd:string |
| http://purl.uniprot.org/citations/22778137 | http://purl.uniprot.org/core/author | "Martens A."xsd:string |
| http://purl.uniprot.org/citations/22778137 | http://purl.uniprot.org/core/author | "Hofhuis F."xsd:string |
| http://purl.uniprot.org/citations/22778137 | http://purl.uniprot.org/core/author | "DeKoter R.P."xsd:string |
| http://purl.uniprot.org/citations/22778137 | http://purl.uniprot.org/core/date | "2012"xsd:gYear |
| http://purl.uniprot.org/citations/22778137 | http://purl.uniprot.org/core/name | "Mol Cell Biol"xsd:string |
| http://purl.uniprot.org/citations/22778137 | http://purl.uniprot.org/core/pages | "3639-3647"xsd:string |
| http://purl.uniprot.org/citations/22778137 | http://purl.uniprot.org/core/title | "Peyer's patch M cells derived from Lgr5(+) stem cells require SpiB and are induced by RankL in cultured "miniguts"."xsd:string |
| http://purl.uniprot.org/citations/22778137 | http://purl.uniprot.org/core/volume | "32"xsd:string |
| http://purl.uniprot.org/citations/22778137 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/22778137 |
| http://purl.uniprot.org/citations/22778137 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/22778137 |
| http://purl.uniprot.org/uniprot/#_A0A0G2JGQ0-mappedCitation-22778137 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/22778137 |
| http://purl.uniprot.org/uniprot/#_A0A0R4J0B9-mappedCitation-22778137 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/22778137 |
| http://purl.uniprot.org/uniprot/#_A0A0U1RPG0-mappedCitation-22778137 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/22778137 |