| http://purl.uniprot.org/citations/22787226 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/22787226 | http://www.w3.org/2000/01/rdf-schema#comment | "Limited protection of current vaccines and antiviral drugs against influenza A virus infection underscores the urgent need for development of novel anti-influenza virus interventions. While short interfering RNA (siRNA) has been shown to be able to inhibit influenza virus infection in a gene-specific manner, activation of the retinoic acid-inducible gene I protein (RIG-I) pathway has an antiviral effect in a non-gene-specific mode. In this study, we designed and tested the anti-influenza virus effect of a short double-stranded RNA, designated 3p-mNP1496-siRNA, that possesses dual functions: an siRNA-targeting influenza NP gene and an agonist for RIG-I activation. This double-stranded siRNA possesses a triphosphate group at the 5' end of the sense strand and is blunt ended. Our study showed that 3p-mNP1496-siRNA could potently inhibit influenza A virus infection both in cell culture and in mice. The strong inhibition effect was attributed to its siRNA function as well as its ability to activate the RIG-I pathway. To the best of our knowledge, this is the first report that the combination of siRNA and RIG-I pathway activation can synergistically inhibit influenza A virus infection. The development of such dual functional RNA molecules will greatly contribute to the arsenal of tools to combat not only influenza viruses but also other important viral pathogens."xsd:string |
| http://purl.uniprot.org/citations/22787226 | http://purl.org/dc/terms/identifier | "doi:10.1128/jvi.00665-12"xsd:string |
| http://purl.uniprot.org/citations/22787226 | http://purl.uniprot.org/core/author | "Liu Q."xsd:string |
| http://purl.uniprot.org/citations/22787226 | http://purl.uniprot.org/core/author | "Lin L."xsd:string |
| http://purl.uniprot.org/citations/22787226 | http://purl.uniprot.org/core/author | "Zhou Y."xsd:string |
| http://purl.uniprot.org/citations/22787226 | http://purl.uniprot.org/core/author | "Berube N."xsd:string |
| http://purl.uniprot.org/citations/22787226 | http://purl.uniprot.org/core/author | "Detmer S."xsd:string |
| http://purl.uniprot.org/citations/22787226 | http://purl.uniprot.org/core/date | "2012"xsd:gYear |
| http://purl.uniprot.org/citations/22787226 | http://purl.uniprot.org/core/name | "J Virol"xsd:string |
| http://purl.uniprot.org/citations/22787226 | http://purl.uniprot.org/core/pages | "10359-10369"xsd:string |
| http://purl.uniprot.org/citations/22787226 | http://purl.uniprot.org/core/title | "5'-Triphosphate-short interfering RNA: potent inhibition of influenza A virus infection by gene silencing and RIG-I activation."xsd:string |
| http://purl.uniprot.org/citations/22787226 | http://purl.uniprot.org/core/volume | "86"xsd:string |
| http://purl.uniprot.org/citations/22787226 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/22787226 |
| http://purl.uniprot.org/citations/22787226 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/22787226 |
| http://purl.uniprot.org/uniprot/#_A1L0V6-mappedCitation-22787226 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/22787226 |
| http://purl.uniprot.org/uniprot/#_A7YY79-mappedCitation-22787226 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/22787226 |
| http://purl.uniprot.org/uniprot/#_B3KN51-mappedCitation-22787226 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/22787226 |
| http://purl.uniprot.org/uniprot/#_B4DWT9-mappedCitation-22787226 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/22787226 |
| http://purl.uniprot.org/uniprot/#_B3KWW1-mappedCitation-22787226 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/22787226 |
| http://purl.uniprot.org/uniprot/#_Q3B797-mappedCitation-22787226 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/22787226 |
| http://purl.uniprot.org/uniprot/#_Q05CC6-mappedCitation-22787226 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/22787226 |
| http://purl.uniprot.org/uniprot/#_L8E813-mappedCitation-22787226 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/22787226 |
| http://purl.uniprot.org/uniprot/#_O95786-mappedCitation-22787226 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/22787226 |
| http://purl.uniprot.org/uniprot/#_Q3KQQ7-mappedCitation-22787226 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/22787226 |