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http://purl.uniprot.org/citations/22791893http://www.w3.org/1999/02/22-rdf-syntax-ns#typehttp://purl.uniprot.org/core/Journal_Citation
http://purl.uniprot.org/citations/22791893http://www.w3.org/1999/02/22-rdf-syntax-ns#typehttp://purl.uniprot.org/core/Journal_Citation
http://purl.uniprot.org/citations/22791893http://www.w3.org/2000/01/rdf-schema#comment"A crucial regulator of Cxcl12 is the decoy receptor Cxcr7, which controls the level of the chemokine in the tissue. The molecular mechanisms that enable Cxcr7 to function as an efficient molecular sink are not known. Using zebrafish primordial germ cells as a model, we identify a novel role for β-arrestins in controlling the intracellular trafficking of Cxcr7. β-arrestins facilitate the recycling of Cxcr7 from late endosomal compartments back to the plasma membrane, whereas the internalized ligand undergoes lysosomal degradation. β-arrestins thus function in regulating chemokine gradient formation, allowing responding cells to discriminate between alternative migration targets in vivo."xsd:string
http://purl.uniprot.org/citations/22791893http://purl.org/dc/terms/identifier"doi:10.1242/dev.080408"xsd:string
http://purl.uniprot.org/citations/22791893http://purl.uniprot.org/core/author"Nowak M."xsd:string
http://purl.uniprot.org/citations/22791893http://purl.uniprot.org/core/author"Nowak M."xsd:string
http://purl.uniprot.org/citations/22791893http://purl.uniprot.org/core/author"Mahabaleshwar H."xsd:string
http://purl.uniprot.org/citations/22791893http://purl.uniprot.org/core/author"Mahabaleshwar H."xsd:string
http://purl.uniprot.org/citations/22791893http://purl.uniprot.org/core/author"Raz E."xsd:string
http://purl.uniprot.org/citations/22791893http://purl.uniprot.org/core/author"Raz E."xsd:string
http://purl.uniprot.org/citations/22791893http://purl.uniprot.org/core/author"Brand M."xsd:string
http://purl.uniprot.org/citations/22791893http://purl.uniprot.org/core/author"Brand M."xsd:string
http://purl.uniprot.org/citations/22791893http://purl.uniprot.org/core/author"Tarbashevich K."xsd:string
http://purl.uniprot.org/citations/22791893http://purl.uniprot.org/core/author"Tarbashevich K."xsd:string
http://purl.uniprot.org/citations/22791893http://purl.uniprot.org/core/date"2012"xsd:gYear
http://purl.uniprot.org/citations/22791893http://purl.uniprot.org/core/date"2012"xsd:gYear
http://purl.uniprot.org/citations/22791893http://purl.uniprot.org/core/name"Development"xsd:string
http://purl.uniprot.org/citations/22791893http://purl.uniprot.org/core/name"Development"xsd:string
http://purl.uniprot.org/citations/22791893http://purl.uniprot.org/core/pages"2897-2902"xsd:string
http://purl.uniprot.org/citations/22791893http://purl.uniprot.org/core/pages"2897-2902"xsd:string
http://purl.uniprot.org/citations/22791893http://purl.uniprot.org/core/title"beta-arrestin control of late endosomal sorting facilitates decoy receptor function and chemokine gradient formation."xsd:string
http://purl.uniprot.org/citations/22791893http://purl.uniprot.org/core/title"beta-arrestin control of late endosomal sorting facilitates decoy receptor function and chemokine gradient formation."xsd:string
http://purl.uniprot.org/citations/22791893http://purl.uniprot.org/core/volume"139"xsd:string
http://purl.uniprot.org/citations/22791893http://purl.uniprot.org/core/volume"139"xsd:string
http://purl.uniprot.org/citations/22791893http://www.w3.org/2004/02/skos/core#exactMatchhttp://purl.uniprot.org/pubmed/22791893