| http://purl.uniprot.org/citations/22795247 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/22795247 | http://www.w3.org/2000/01/rdf-schema#comment | "UnlabelledWe previously showed evidence for a genetic association of the human leukocyte antigen (HLA) system and complex regional pain syndrome (CRPS) with dystonia. Involvement of the HLA system suggests that CRPS has a genetic component with perturbed regulation of inflammation and neuroplasticity as possible disease mechanisms. However, it is at present unclear whether the observed association with HLA-B62 and HLA-DQ8 in CRPS patients with dystonia also holds true for patients without dystonia. Therefore, we tested the possible association with HLA-B62 and HLA-DQ8 in a clinically homogeneous group of 131 CRPS patients without dystonia. In addition, we investigated the possible association with other alleles of the HLA-A, HLA-B, HLA-C, HLA-DR, and HLA-DQ loci. We showed an increased prevalence of HLA-DQ8 (molecularly typed as HLA-DQB1*03:02; OR = 1.65 [95% CI 1.12-2.42], P = .014) in CRPS without dystonia, whereas no association was observed for HLA-B62 (molecularly typed as HLA-B*15:01; OR = 1.22 [95% CI .78-1.92], P = .458). Our data suggest that CRPS with and CRPS without dystonia may be genetically different, but overlapping, disease entities because only HLA-DQ8 is associated with both. The findings also indicate that distinct biological pathways may play a role in both CRPS subtypes.PerspectiveThis study is the first to replicate a specific HLA region conferring genetic risk for the development of CRPS. Moreover, associations of HLA-DQ8 with both CRPS with and CRPS without dystonia, and HLA-B62 only with CRPS with dystonia, suggest that these disease entities may be genetically different, but overlapping."xsd:string |
| http://purl.uniprot.org/citations/22795247 | http://purl.org/dc/terms/identifier | "doi:10.1016/j.jpain.2012.05.003"xsd:string |
| http://purl.uniprot.org/citations/22795247 | http://purl.uniprot.org/core/author | "Claas F.H."xsd:string |
| http://purl.uniprot.org/citations/22795247 | http://purl.uniprot.org/core/author | "van den Maagdenberg A.M."xsd:string |
| http://purl.uniprot.org/citations/22795247 | http://purl.uniprot.org/core/author | "Verduijn W."xsd:string |
| http://purl.uniprot.org/citations/22795247 | http://purl.uniprot.org/core/author | "van Hilten J.J."xsd:string |
| http://purl.uniprot.org/citations/22795247 | http://purl.uniprot.org/core/author | "Haasnoot G.W."xsd:string |
| http://purl.uniprot.org/citations/22795247 | http://purl.uniprot.org/core/author | "Roelen D.L."xsd:string |
| http://purl.uniprot.org/citations/22795247 | http://purl.uniprot.org/core/author | "Huygen F.J."xsd:string |
| http://purl.uniprot.org/citations/22795247 | http://purl.uniprot.org/core/author | "Perez R.S."xsd:string |
| http://purl.uniprot.org/citations/22795247 | http://purl.uniprot.org/core/author | "Marinus J."xsd:string |
| http://purl.uniprot.org/citations/22795247 | http://purl.uniprot.org/core/author | "van Rooijen D.E."xsd:string |
| http://purl.uniprot.org/citations/22795247 | http://purl.uniprot.org/core/date | "2012"xsd:gYear |
| http://purl.uniprot.org/citations/22795247 | http://purl.uniprot.org/core/name | "J Pain"xsd:string |
| http://purl.uniprot.org/citations/22795247 | http://purl.uniprot.org/core/pages | "784-789"xsd:string |
| http://purl.uniprot.org/citations/22795247 | http://purl.uniprot.org/core/title | "Genetic HLA associations in complex regional pain syndrome with and without dystonia."xsd:string |
| http://purl.uniprot.org/citations/22795247 | http://purl.uniprot.org/core/volume | "13"xsd:string |
| http://purl.uniprot.org/citations/22795247 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/22795247 |
| http://purl.uniprot.org/citations/22795247 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/22795247 |
| http://purl.uniprot.org/uniprot/#_A0A0A7C552-mappedCitation-22795247 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/22795247 |
| http://purl.uniprot.org/uniprot/#_A0A0E3DC98-mappedCitation-22795247 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/22795247 |
| http://purl.uniprot.org/uniprot/#_A0A0E3DCA0-mappedCitation-22795247 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/22795247 |
| http://purl.uniprot.org/uniprot/#_A0A0E3DCA1-mappedCitation-22795247 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/22795247 |
| http://purl.uniprot.org/uniprot/#_A0A068B107-mappedCitation-22795247 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/22795247 |