| http://purl.uniprot.org/citations/22798407 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/22798407 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/22798407 | http://www.w3.org/2000/01/rdf-schema#comment | "Impairment of the circadian clock has been associated with numerous disorders, including metabolic disease. Although small molecules that modulate clock function might offer therapeutic approaches to such diseases, only a few compounds have been identified that selectively target core clock proteins. From an unbiased cell-based circadian phenotypic screen, we identified KL001, a small molecule that specifically interacts with cryptochrome (CRY). KL001 prevented ubiquitin-dependent degradation of CRY, resulting in lengthening of the circadian period. In combination with mathematical modeling, our studies using KL001 revealed that CRY1 and CRY2 share a similar functional role in the period regulation. Furthermore, KL001-mediated CRY stabilization inhibited glucagon-induced gluconeogenesis in primary hepatocytes. KL001 thus provides a tool to study the regulation of CRY-dependent physiology and aid development of clock-based therapeutics of diabetes."xsd:string |
| http://purl.uniprot.org/citations/22798407 | http://purl.org/dc/terms/identifier | "doi:10.1126/science.1223710"xsd:string |
| http://purl.uniprot.org/citations/22798407 | http://purl.org/dc/terms/identifier | "doi:10.1126/science.1223710"xsd:string |
| http://purl.uniprot.org/citations/22798407 | http://purl.uniprot.org/core/author | "Kay S.A."xsd:string |
| http://purl.uniprot.org/citations/22798407 | http://purl.uniprot.org/core/author | "Kay S.A."xsd:string |
| http://purl.uniprot.org/citations/22798407 | http://purl.uniprot.org/core/author | "Lee J.W."xsd:string |
| http://purl.uniprot.org/citations/22798407 | http://purl.uniprot.org/core/author | "Lee J.W."xsd:string |
| http://purl.uniprot.org/citations/22798407 | http://purl.uniprot.org/core/author | "Schultz P.G."xsd:string |
| http://purl.uniprot.org/citations/22798407 | http://purl.uniprot.org/core/author | "Schultz P.G."xsd:string |
| http://purl.uniprot.org/citations/22798407 | http://purl.uniprot.org/core/author | "Sonntag T."xsd:string |
| http://purl.uniprot.org/citations/22798407 | http://purl.uniprot.org/core/author | "Sonntag T."xsd:string |
| http://purl.uniprot.org/citations/22798407 | http://purl.uniprot.org/core/author | "Sawa M."xsd:string |
| http://purl.uniprot.org/citations/22798407 | http://purl.uniprot.org/core/author | "Sawa M."xsd:string |
| http://purl.uniprot.org/citations/22798407 | http://purl.uniprot.org/core/author | "Noguchi T."xsd:string |
| http://purl.uniprot.org/citations/22798407 | http://purl.uniprot.org/core/author | "Noguchi T."xsd:string |
| http://purl.uniprot.org/citations/22798407 | http://purl.uniprot.org/core/author | "Hirota T."xsd:string |
| http://purl.uniprot.org/citations/22798407 | http://purl.uniprot.org/core/author | "Hirota T."xsd:string |
| http://purl.uniprot.org/citations/22798407 | http://purl.uniprot.org/core/author | "Brenner D.A."xsd:string |
| http://purl.uniprot.org/citations/22798407 | http://purl.uniprot.org/core/author | "Brenner D.A."xsd:string |
| http://purl.uniprot.org/citations/22798407 | http://purl.uniprot.org/core/author | "Welsh D.K."xsd:string |
| http://purl.uniprot.org/citations/22798407 | http://purl.uniprot.org/core/author | "Welsh D.K."xsd:string |
| http://purl.uniprot.org/citations/22798407 | http://purl.uniprot.org/core/author | "Pongsawakul P.Y."xsd:string |
| http://purl.uniprot.org/citations/22798407 | http://purl.uniprot.org/core/author | "Pongsawakul P.Y."xsd:string |