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| http://purl.uniprot.org/citations/22800759 | http://www.w3.org/2000/01/rdf-schema#comment | "The dorsomedial hypothalamic nucleus (DMH) has been proposed as a candidate for the neural substrate of a food-entrainable oscillator. The existence of a food-entrainable oscillator in the mammalian nervous system was inferred previously from restricted feeding-induced behavioral rhythmicity in rodents with suprachiasmatic nucleus lesions. In the present study, we have characterized the circadian rhythmicity of behavior in Wfs1-deficient mice during ad libitum and restricted feeding. Based on the expression of Wfs1 protein in the DMH it was hypothesized that Wfs1-deficient mice will display reduced or otherwise altered food anticipatory activity. Wfs1 immunoreactivity in DMH was found almost exclusively in the compact part. Restricted feeding induced c-Fos immunoreactivity primarily in the ventral and lateral aspects of DMH and it was similar in both genotypes. Wfs1-deficiency resulted in significantly lower body weight and reduced wheel-running activity. Circadian rhythmicity of behavior was normal in Wfs1-deficient mice under ad libitum feeding apart from elongated free-running period in constant light. The amount of food anticipatory activity induced by restricted feeding was not significantly different between the genotypes. Present results indicate that the effects of Wfs1-deficiency on behavioral rhythmicity are subtle suggesting that Wfs1 is not a major player in the neural networks responsible for circadian rhythmicity of behavior."xsd:string |
| http://purl.uniprot.org/citations/22800759 | http://purl.org/dc/terms/identifier | "doi:10.1016/j.bbrc.2012.07.017"xsd:string |
| http://purl.uniprot.org/citations/22800759 | http://purl.uniprot.org/core/author | "Fahrenkrug J."xsd:string |
| http://purl.uniprot.org/citations/22800759 | http://purl.uniprot.org/core/author | "Hannibal J."xsd:string |
| http://purl.uniprot.org/citations/22800759 | http://purl.uniprot.org/core/author | "Luuk H."xsd:string |
| http://purl.uniprot.org/citations/22800759 | http://purl.uniprot.org/core/date | "2012"xsd:gYear |
| http://purl.uniprot.org/citations/22800759 | http://purl.uniprot.org/core/name | "Biochem Biophys Res Commun"xsd:string |
| http://purl.uniprot.org/citations/22800759 | http://purl.uniprot.org/core/pages | "717-723"xsd:string |
| http://purl.uniprot.org/citations/22800759 | http://purl.uniprot.org/core/title | "Circadian rhythms and food anticipatory behavior in Wfs1-deficient mice."xsd:string |
| http://purl.uniprot.org/citations/22800759 | http://purl.uniprot.org/core/volume | "424"xsd:string |
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