| http://purl.uniprot.org/citations/22802532 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/22802532 | http://www.w3.org/2000/01/rdf-schema#comment | "Two polypyrimidine tract RNA-binding proteins (PTBs), one near-ubiquitously expressed (Ptbp1) and another highly tissue-restricted (Ptbp2), regulate RNA in interrelated but incompletely understood ways. Ptbp1, a splicing regulator, is replaced in the brain and differentiated neuronal cell lines by Ptbp2. To define the roles of Ptbp2 in the nervous system, we generated two independent Ptbp2-null strains, unexpectedly revealing that Ptbp2 is expressed in neuronal progenitors and is essential for postnatal survival. A HITS-CLIP (high-throughput sequencing cross-linking immunoprecipitation)-generated map of reproducible Ptbp2-RNA interactions in the developing mouse neocortex, combined with results from splicing-sensitive microarrays, demonstrated that the major action of Ptbp2 is to inhibit adult-specific alternative exons by binding pyrimidine-rich sequences upstream of and/or within them. These regulated exons are present in mRNAs encoding proteins associated with control of cell fate, proliferation, and the actin cytoskeleton, suggesting a role for Ptbp2 in neurogenesis. Indeed, neuronal progenitors in the Ptbp2-null brain exhibited an aberrant polarity and were associated with regions of premature neurogenesis and reduced progenitor pools. Thus, Ptbp2 inhibition of a discrete set of adult neuronal exons underlies early brain development prior to neuronal differentiation and is essential for postnatal survival."xsd:string |
| http://purl.uniprot.org/citations/22802532 | http://purl.org/dc/terms/identifier | "doi:10.1101/gad.191338.112"xsd:string |
| http://purl.uniprot.org/citations/22802532 | http://purl.uniprot.org/core/author | "Zhang C."xsd:string |
| http://purl.uniprot.org/citations/22802532 | http://purl.uniprot.org/core/author | "Yano M."xsd:string |
| http://purl.uniprot.org/citations/22802532 | http://purl.uniprot.org/core/author | "Darnell R.B."xsd:string |
| http://purl.uniprot.org/citations/22802532 | http://purl.uniprot.org/core/author | "Fak J.J."xsd:string |
| http://purl.uniprot.org/citations/22802532 | http://purl.uniprot.org/core/author | "Mele A."xsd:string |
| http://purl.uniprot.org/citations/22802532 | http://purl.uniprot.org/core/author | "Licatalosi D.D."xsd:string |
| http://purl.uniprot.org/citations/22802532 | http://purl.uniprot.org/core/author | "Grabinski S.E."xsd:string |
| http://purl.uniprot.org/citations/22802532 | http://purl.uniprot.org/core/date | "2012"xsd:gYear |
| http://purl.uniprot.org/citations/22802532 | http://purl.uniprot.org/core/name | "Genes Dev"xsd:string |
| http://purl.uniprot.org/citations/22802532 | http://purl.uniprot.org/core/pages | "1626-1642"xsd:string |
| http://purl.uniprot.org/citations/22802532 | http://purl.uniprot.org/core/title | "Ptbp2 represses adult-specific splicing to regulate the generation of neuronal precursors in the embryonic brain."xsd:string |
| http://purl.uniprot.org/citations/22802532 | http://purl.uniprot.org/core/volume | "26"xsd:string |
| http://purl.uniprot.org/citations/22802532 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/22802532 |
| http://purl.uniprot.org/citations/22802532 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/22802532 |
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