| http://purl.uniprot.org/citations/22802649 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/22802649 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/22802649 | http://www.w3.org/2000/01/rdf-schema#comment | "Interleukin 20 (IL-20) is a pleotropic IL-10 family cytokine that protects epithelial surfaces from pathogens. However, dysregulated IL-20 signaling is implicated in several human pathologies including psoriasis, rheumatoid arthritis, atherosclerosis, and osteoporosis. IL-20, and related cytokines IL-19 and IL-24, designated IL-20 subfamily cytokines (IL-20SFCs), induce cellular responses through an IL-20R1/IL-20R2 (type I) receptor heterodimer, whereas IL-20 and IL-24 also signal through the IL-22R1/IL-20R2 (type II) receptor complex. The crystal structure of the IL-20/IL-20R1/IL-20R2 complex reveals how type I and II complexes discriminate cognate from noncognate ligands. The structure also defines how the receptor-cytokine interfaces are affinity tuned to allow distinct signaling through a receptor complex shared by three different ligands. Our results provide unique insights into the complexity of IL-20SFC signaling that may be critical in the design of mechanistic-based inhibitors of IL-20SFC-mediated inflammatory disease."xsd:string |
| http://purl.uniprot.org/citations/22802649 | http://purl.org/dc/terms/identifier | "doi:10.1073/pnas.1117551109"xsd:string |
| http://purl.uniprot.org/citations/22802649 | http://purl.org/dc/terms/identifier | "doi:10.1073/pnas.1117551109"xsd:string |
| http://purl.uniprot.org/citations/22802649 | http://purl.uniprot.org/core/author | "Rajashankar K.R."xsd:string |
| http://purl.uniprot.org/citations/22802649 | http://purl.uniprot.org/core/author | "Rajashankar K.R."xsd:string |
| http://purl.uniprot.org/citations/22802649 | http://purl.uniprot.org/core/author | "Logsdon N.J."xsd:string |
| http://purl.uniprot.org/citations/22802649 | http://purl.uniprot.org/core/author | "Logsdon N.J."xsd:string |
| http://purl.uniprot.org/citations/22802649 | http://purl.uniprot.org/core/author | "Walter M.R."xsd:string |
| http://purl.uniprot.org/citations/22802649 | http://purl.uniprot.org/core/author | "Walter M.R."xsd:string |
| http://purl.uniprot.org/citations/22802649 | http://purl.uniprot.org/core/author | "Deshpande A."xsd:string |
| http://purl.uniprot.org/citations/22802649 | http://purl.uniprot.org/core/author | "Deshpande A."xsd:string |
| http://purl.uniprot.org/citations/22802649 | http://purl.uniprot.org/core/author | "Harris B.D."xsd:string |
| http://purl.uniprot.org/citations/22802649 | http://purl.uniprot.org/core/author | "Harris B.D."xsd:string |
| http://purl.uniprot.org/citations/22802649 | http://purl.uniprot.org/core/date | "2012"xsd:gYear |
| http://purl.uniprot.org/citations/22802649 | http://purl.uniprot.org/core/date | "2012"xsd:gYear |
| http://purl.uniprot.org/citations/22802649 | http://purl.uniprot.org/core/name | "Proc. Natl. Acad. Sci. U.S.A."xsd:string |
| http://purl.uniprot.org/citations/22802649 | http://purl.uniprot.org/core/name | "Proc. Natl. Acad. Sci. U.S.A."xsd:string |
| http://purl.uniprot.org/citations/22802649 | http://purl.uniprot.org/core/pages | "12704-12709"xsd:string |
| http://purl.uniprot.org/citations/22802649 | http://purl.uniprot.org/core/pages | "12704-12709"xsd:string |
| http://purl.uniprot.org/citations/22802649 | http://purl.uniprot.org/core/title | "Structural basis for receptor sharing and activation by interleukin-20 receptor-2 (IL-20R2) binding cytokines."xsd:string |
| http://purl.uniprot.org/citations/22802649 | http://purl.uniprot.org/core/title | "Structural basis for receptor sharing and activation by interleukin-20 receptor-2 (IL-20R2) binding cytokines."xsd:string |
| http://purl.uniprot.org/citations/22802649 | http://purl.uniprot.org/core/volume | "109"xsd:string |
| http://purl.uniprot.org/citations/22802649 | http://purl.uniprot.org/core/volume | "109"xsd:string |