http://purl.uniprot.org/citations/22803655 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
http://purl.uniprot.org/citations/22803655 | http://www.w3.org/2000/01/rdf-schema#comment | "The objective of this study was to investigate human leucocyte antigen (HLA) genes in patients chronically infected with hepatitis C virus (HCV) and to analyse the possible role of these genes in the progression of chronic hepatitis C. One hundred and forty-five (145) Brazilian patients infected only with HCV genotype 1 were evaluated. HLA class I (A, B, C) and class II (DRB1, DQA1, DQB1) typing were carried out by PCR-SSO, through Luminex technology. Associations were found with protection against development of liver damage by both DRB1 11 (5.0% versus 18.2%, P=0.0016, OR=0.23, CI 95% = 0.09-0.58; Pc=0.0208) and DRB1 11-DQA1 05-DQB1 03 haplotype (4.2% versus 15.3%, P=0.0032; OR = 0.24, CI 95% = 0.08-0.64). Liver damage was associated with HLA-C 04 in patients with <20 years of infection (38.4% versus 9.1%, P = 0.002, OR = 6.25, CI 95%=1.97-19.7; Pc=0.0238). It is concluded that HLA alleles can influence the development of liver damage in HCV type-1 chronically infected Brazilian patients."xsd:string |
http://purl.uniprot.org/citations/22803655 | http://purl.org/dc/terms/identifier | "doi:10.1111/j.1365-3083.2012.02755.x"xsd:string |
http://purl.uniprot.org/citations/22803655 | http://purl.uniprot.org/core/author | "Silva G.F."xsd:string |
http://purl.uniprot.org/citations/22803655 | http://purl.uniprot.org/core/author | "Pardini M.I."xsd:string |
http://purl.uniprot.org/citations/22803655 | http://purl.uniprot.org/core/author | "Moliterno R.A."xsd:string |
http://purl.uniprot.org/citations/22803655 | http://purl.uniprot.org/core/author | "Visentainer J.E."xsd:string |
http://purl.uniprot.org/citations/22803655 | http://purl.uniprot.org/core/author | "Sell A.M."xsd:string |
http://purl.uniprot.org/citations/22803655 | http://purl.uniprot.org/core/author | "Marangon A.V."xsd:string |
http://purl.uniprot.org/citations/22803655 | http://purl.uniprot.org/core/author | "Grotto R.M."xsd:string |
http://purl.uniprot.org/citations/22803655 | http://purl.uniprot.org/core/author | "de Moraes C.F."xsd:string |
http://purl.uniprot.org/citations/22803655 | http://purl.uniprot.org/core/author | "de Pauli D.S."xsd:string |
http://purl.uniprot.org/citations/22803655 | http://purl.uniprot.org/core/date | "2012"xsd:gYear |
http://purl.uniprot.org/citations/22803655 | http://purl.uniprot.org/core/name | "Scand J Immunol"xsd:string |
http://purl.uniprot.org/citations/22803655 | http://purl.uniprot.org/core/pages | "440-447"xsd:string |
http://purl.uniprot.org/citations/22803655 | http://purl.uniprot.org/core/title | "Protective effect of HLA-DRB1 11 and predisposition of HLA-C 04 in the development of severe liver damage in Brazilian patients with chronic hepatitis C virus infection."xsd:string |
http://purl.uniprot.org/citations/22803655 | http://purl.uniprot.org/core/volume | "76"xsd:string |
http://purl.uniprot.org/citations/22803655 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/22803655 |
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