| http://purl.uniprot.org/citations/22806691 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/22806691 | http://www.w3.org/2000/01/rdf-schema#comment | "Fms-like tyrosine kinase 3 ligand (Flt3L) is a major cytokine that drives development of dendritic cells (DCs) under steady state, whereas GM-CSF becomes a prominent influence on differentiation during inflammation. The influence GM-CSF exerts on Flt3L-induced DC development has not been thoroughly examined. Here, we report that GM-CSF alters Flt3L-induced DC development. When BM cells were cultured with both Flt3L and GM-CSF, few CD8⁺ equivalent DCs or plasmacytoid DCs developed compared to cultures supplemented with Flt3L alone. The disappearance of these two cell subsets in GM-CSF + Flt3L culture was not a result of simple inhibition of their development, but a diversion of the original differentiation trajectory to form a new cell population. As a consequence, both DC progeny and their functions were altered. The effect of GM-CSF on DC subset development was confirmed in vivo. First, the CD8⁺ DC numbers were increased under GM-CSF deficiency (when either GM-CSF or its receptor was ablated). Second, this population was decreased under GM-CSF hyperexpression (by transgenesis or by Listeria infection). Our finding that GM-CSF dominantly changes the regulation of DC development in vitro and in vivo has important implications for inflammatory diseases or GM-CSF therapy."xsd:string |
| http://purl.uniprot.org/citations/22806691 | http://purl.org/dc/terms/identifier | "doi:10.1002/eji.201242477"xsd:string |
| http://purl.uniprot.org/citations/22806691 | http://purl.uniprot.org/core/author | "Xu Y."xsd:string |
| http://purl.uniprot.org/citations/22806691 | http://purl.uniprot.org/core/author | "Zhan Y."xsd:string |
| http://purl.uniprot.org/citations/22806691 | http://purl.uniprot.org/core/author | "Lew A.M."xsd:string |
| http://purl.uniprot.org/citations/22806691 | http://purl.uniprot.org/core/author | "Villadangos J.A."xsd:string |
| http://purl.uniprot.org/citations/22806691 | http://purl.uniprot.org/core/author | "Vega-Ramos J."xsd:string |
| http://purl.uniprot.org/citations/22806691 | http://purl.uniprot.org/core/author | "Carrington E.M."xsd:string |
| http://purl.uniprot.org/citations/22806691 | http://purl.uniprot.org/core/date | "2012"xsd:gYear |
| http://purl.uniprot.org/citations/22806691 | http://purl.uniprot.org/core/name | "Eur J Immunol"xsd:string |
| http://purl.uniprot.org/citations/22806691 | http://purl.uniprot.org/core/pages | "2889-2900"xsd:string |
| http://purl.uniprot.org/citations/22806691 | http://purl.uniprot.org/core/title | "The inflammatory cytokine, GM-CSF, alters the developmental outcome of murine dendritic cells."xsd:string |
| http://purl.uniprot.org/citations/22806691 | http://purl.uniprot.org/core/volume | "42"xsd:string |
| http://purl.uniprot.org/citations/22806691 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/22806691 |
| http://purl.uniprot.org/citations/22806691 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/22806691 |
| http://purl.uniprot.org/uniprot/#_A0A2R8VHF2-mappedCitation-22806691 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/22806691 |
| http://purl.uniprot.org/uniprot/#_A0A2R8VK01-mappedCitation-22806691 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/22806691 |
| http://purl.uniprot.org/uniprot/#_A0A338P6R9-mappedCitation-22806691 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/22806691 |
| http://purl.uniprot.org/uniprot/#_Q14AD9-mappedCitation-22806691 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/22806691 |
| http://purl.uniprot.org/uniprot/#_Q3V057-mappedCitation-22806691 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/22806691 |
| http://purl.uniprot.org/uniprot/#_P01587-mappedCitation-22806691 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/22806691 |
| http://purl.uniprot.org/uniprot/#_P26955-mappedCitation-22806691 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/22806691 |
| http://purl.uniprot.org/uniprot/#_Q3TB34-mappedCitation-22806691 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/22806691 |
| http://purl.uniprot.org/uniprot/#_Q3TDH1-mappedCitation-22806691 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/22806691 |