| http://purl.uniprot.org/citations/22807207 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/22807207 | http://www.w3.org/2000/01/rdf-schema#comment | "Two genome-wide association studies (GWASs) recently highlighted the HLA-DRA and HLA-DRB5 genes as associated with Parkinson disease (PD). However, because HLA-DRA displays a low level of polymorphisms and HLA-DRB5 is only present in approximately 20% of the population, these findings are difficult to interpret. Our aims were: (1) to replicate and investigate in greater detail the association between PD and the HLA-DR region; (2) to identify PD-associated HLA alleles; and (3) to perform a meta-analysis of our top finding. As part of 2 French population-based case-control studies of PD including highly ethnically homogeneous participants, we investigated the association between PD and 51 Single-nucleotide polymorphisms (SNPs) in the HLA-DR region. HLA-DRB1 alleles were imputed using the HLA(*) IMP software. HLA typing was performed in a subsample of the participants. We performed a meta-analysis of our top finding based on 4 GWAS data sets. Among 499 cases and 1123 controls, after correction for multiple testing, we found an association with rs660895 (OR/minor allele, 0.70; 95% CI, 0.57-0.87) within the HLA-DRB1 gene, which encodes the most polymorphic HLA-DR chain (DRβ). A meta-analysis (7996 cases, 36455 controls) confirmed this association (OR, 0.86; 95% CI, 0.82-0.91; P < .0001). SNP-based imputation of HLA alleles showed an inverse association between PD and the HLA-DRB1(*) 04 allele. We replicated an association between PD and the HLA-DR region and provided further insight into the loci and alleles involved. The highly polymorphic HLA-DRB1 locus contains rs660895, which represents a more legitimate candidate than previous ones. Our finding is in agreement with the hypothesis of an immune component in PD pathophysiology."xsd:string |
| http://purl.uniprot.org/citations/22807207 | http://purl.org/dc/terms/identifier | "doi:10.1002/mds.25035"xsd:string |
| http://purl.uniprot.org/citations/22807207 | http://purl.uniprot.org/core/author | "Ahmed I."xsd:string |
| http://purl.uniprot.org/citations/22807207 | http://purl.uniprot.org/core/author | "Lambert J.C."xsd:string |
| http://purl.uniprot.org/citations/22807207 | http://purl.uniprot.org/core/author | "Delord M."xsd:string |
| http://purl.uniprot.org/citations/22807207 | http://purl.uniprot.org/core/author | "Beaune P."xsd:string |
| http://purl.uniprot.org/citations/22807207 | http://purl.uniprot.org/core/author | "Laurent-Puig P."xsd:string |
| http://purl.uniprot.org/citations/22807207 | http://purl.uniprot.org/core/author | "Charron D."xsd:string |
| http://purl.uniprot.org/citations/22807207 | http://purl.uniprot.org/core/author | "Krishnamoorthy R."xsd:string |
| http://purl.uniprot.org/citations/22807207 | http://purl.uniprot.org/core/author | "Elbaz A."xsd:string |
| http://purl.uniprot.org/citations/22807207 | http://purl.uniprot.org/core/author | "Tzourio C."xsd:string |
| http://purl.uniprot.org/citations/22807207 | http://purl.uniprot.org/core/author | "Tamouza R."xsd:string |
| http://purl.uniprot.org/citations/22807207 | http://purl.uniprot.org/core/author | "Loriot M.A."xsd:string |
| http://purl.uniprot.org/citations/22807207 | http://purl.uniprot.org/core/author | "Nacfer M."xsd:string |
| http://purl.uniprot.org/citations/22807207 | http://purl.uniprot.org/core/author | "Mulot C."xsd:string |
| http://purl.uniprot.org/citations/22807207 | http://purl.uniprot.org/core/date | "2012"xsd:gYear |
| http://purl.uniprot.org/citations/22807207 | http://purl.uniprot.org/core/name | "Mov Disord"xsd:string |
| http://purl.uniprot.org/citations/22807207 | http://purl.uniprot.org/core/pages | "1104-1110"xsd:string |
| http://purl.uniprot.org/citations/22807207 | http://purl.uniprot.org/core/title | "Association between Parkinson's disease and the HLA-DRB1 locus."xsd:string |
| http://purl.uniprot.org/citations/22807207 | http://purl.uniprot.org/core/volume | "27"xsd:string |
| http://purl.uniprot.org/citations/22807207 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/22807207 |
| http://purl.uniprot.org/citations/22807207 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/22807207 |
| http://purl.uniprot.org/uniprot/#_A0A0A7C3H3-mappedCitation-22807207 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/22807207 |
| http://purl.uniprot.org/uniprot/#_A0A0A7C3I1-mappedCitation-22807207 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/22807207 |