| http://purl.uniprot.org/citations/22808156 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/22808156 | http://www.w3.org/2000/01/rdf-schema#comment | "The vestibular organs consist of complementary sensors: the semicircular canals detect rotations while the otoliths detect linear accelerations, including the constant pull of gravity. Several fundamental questions remain on how the vestibular system would develop and/or adapt to prolonged changes in gravity such as during long-term space journey. How do vestibular reflexes develop if the appropriate assembly of otoliths and semi-circular canals is perturbed? The aim of present work was to evaluate the role of gravity sensing during ontogeny of the vestibular system. In otoconia-deficient mice (ied), gravity cannot be sensed and therefore maculo-ocular reflexes (MOR) were absent. While canals-related reflexes were present, the ied deficit also led to the abnormal spatial tuning of the horizontal angular canal-related VOR. To identify putative otolith-related critical periods, normal C57Bl/6J mice were subjected to 2G hypergravity by chronic centrifugation during different periods of development or adulthood (Adult-HG) and compared to non-centrifuged (control) C57Bl/6J mice. Mice exposed to hypergravity during development had completely normal vestibulo-ocular reflexes 6 months after end of centrifugation. Adult-HG mice all displayed major abnormalities in maculo-ocular reflexe one month after return to normal gravity. During the next 5 months, adaptation to normal gravity occurred in half of the individuals. In summary, genetic suppression of gravity sensing indicated that otolith-related signals might be necessary to ensure proper functioning of canal-related vestibular reflexes. On the other hand, exposure to hypergravity during development was not sufficient to modify durably motor behaviour. Hence, 2G centrifugation during development revealed no otolith-specific critical period."xsd:string |
| http://purl.uniprot.org/citations/22808156 | http://purl.org/dc/terms/identifier | "doi:10.1371/journal.pone.0040414"xsd:string |
| http://purl.uniprot.org/citations/22808156 | http://purl.uniprot.org/core/author | "Beraneck M."xsd:string |
| http://purl.uniprot.org/citations/22808156 | http://purl.uniprot.org/core/author | "Jamon M."xsd:string |
| http://purl.uniprot.org/citations/22808156 | http://purl.uniprot.org/core/author | "Vidal P.P."xsd:string |
| http://purl.uniprot.org/citations/22808156 | http://purl.uniprot.org/core/author | "Bojados M."xsd:string |
| http://purl.uniprot.org/citations/22808156 | http://purl.uniprot.org/core/author | "Le Seac'h A."xsd:string |
| http://purl.uniprot.org/citations/22808156 | http://purl.uniprot.org/core/date | "2012"xsd:gYear |
| http://purl.uniprot.org/citations/22808156 | http://purl.uniprot.org/core/name | "PLoS One"xsd:string |
| http://purl.uniprot.org/citations/22808156 | http://purl.uniprot.org/core/pages | "e40414"xsd:string |
| http://purl.uniprot.org/citations/22808156 | http://purl.uniprot.org/core/title | "Ontogeny of mouse vestibulo-ocular reflex following genetic or environmental alteration of gravity sensing."xsd:string |
| http://purl.uniprot.org/citations/22808156 | http://purl.uniprot.org/core/volume | "7"xsd:string |
| http://purl.uniprot.org/citations/22808156 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/22808156 |
| http://purl.uniprot.org/citations/22808156 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/22808156 |
| http://purl.uniprot.org/uniprot/#_A0A5H1ZRK5-mappedCitation-22808156 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/22808156 |
| http://purl.uniprot.org/uniprot/#_Q80VM9-mappedCitation-22808156 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/22808156 |
| http://purl.uniprot.org/uniprot/Q80VM9 | http://purl.uniprot.org/core/mappedCitation | http://purl.uniprot.org/citations/22808156 |
| http://purl.uniprot.org/uniprot/A0A5H1ZRK5 | http://purl.uniprot.org/core/mappedCitation | http://purl.uniprot.org/citations/22808156 |