| http://purl.uniprot.org/citations/22815195 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/22815195 | http://www.w3.org/2000/01/rdf-schema#comment | "Genetic variability of glycogen synthase kinase-3β (GSK3β) may be linked to Parkinson's disease (PD). Its role in ethnic Chinese population is still unclear. We examined the association between GSK3β variation and PD in a Han Chinese population from mainland China. Using a case-control methodology, we genotyped the single nucleotide polymorphism (SNP) in GSK3β (rs334558) to investigate the association with risk of PD. A total of 1,280 ethnic Han Chinese study subjects comprising 761 sporadic PD patients and 519 controls were recruited. The T allele of a promoter SNP rs334558 was found to reduce the risk of PD (OR = 0.82, 95% CI: 0.696-0.960, P = 0.014). Patients with CT + TT genotypes have a reduced risk of PD compared to those with CC genotype (OR = 0.61, 95% CI: 0.477-0.776, P = 6.09E-5). In addition, we demonstrated that CT + TT subjects cannot be distinguished from CC subjects based on their clinical features. Our data suggest that rs334558 variant in GSK3β reduces the risk of PD in a Han Chinese population from mainland China. Further studies of large series of subjects are necessary to fully elucidate the true role of GSK3β in PD."xsd:string |
| http://purl.uniprot.org/citations/22815195 | http://purl.org/dc/terms/identifier | "doi:10.1002/ajmg.b.32075"xsd:string |
| http://purl.uniprot.org/citations/22815195 | http://purl.uniprot.org/core/author | "Peng R."xsd:string |
| http://purl.uniprot.org/citations/22815195 | http://purl.uniprot.org/core/author | "Tan E.K."xsd:string |
| http://purl.uniprot.org/citations/22815195 | http://purl.uniprot.org/core/author | "Zhang J.H."xsd:string |
| http://purl.uniprot.org/citations/22815195 | http://purl.uniprot.org/core/author | "Liao Q."xsd:string |
| http://purl.uniprot.org/citations/22815195 | http://purl.uniprot.org/core/author | "Zhao D.M."xsd:string |
| http://purl.uniprot.org/citations/22815195 | http://purl.uniprot.org/core/author | "Li N.N."xsd:string |
| http://purl.uniprot.org/citations/22815195 | http://purl.uniprot.org/core/author | "Chang X.L."xsd:string |
| http://purl.uniprot.org/citations/22815195 | http://purl.uniprot.org/core/author | "Mao X.Y."xsd:string |
| http://purl.uniprot.org/citations/22815195 | http://purl.uniprot.org/core/date | "2012"xsd:gYear |
| http://purl.uniprot.org/citations/22815195 | http://purl.uniprot.org/core/name | "Am J Med Genet B Neuropsychiatr Genet"xsd:string |
| http://purl.uniprot.org/citations/22815195 | http://purl.uniprot.org/core/pages | "718-721"xsd:string |
| http://purl.uniprot.org/citations/22815195 | http://purl.uniprot.org/core/title | "GSK3beta reduces risk of sporadic Parkinson's disease in ethnic Chinese."xsd:string |
| http://purl.uniprot.org/citations/22815195 | http://purl.uniprot.org/core/volume | "159B"xsd:string |
| http://purl.uniprot.org/citations/22815195 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/22815195 |
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| http://purl.uniprot.org/uniprot/#_P49841-mappedCitation-22815195 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/22815195 |
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| http://purl.uniprot.org/uniprot/P49841 | http://purl.uniprot.org/core/mappedCitation | http://purl.uniprot.org/citations/22815195 |
| http://purl.uniprot.org/uniprot/Q6FI27 | http://purl.uniprot.org/core/mappedCitation | http://purl.uniprot.org/citations/22815195 |