| http://purl.uniprot.org/citations/22815484 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/22815484 | http://www.w3.org/2000/01/rdf-schema#comment | "Insulin-like growth factors (IGFs) are essential for the development, regeneration, and hypertrophy of skeletal muscles. IGF-II promotes myoblast differentiation through phosphatidylinositol 3-kinase (PI 3-kinase), Akt, and mTOR signaling. Here, we report that skeletal muscle- and kidney-enriched inositol polyphosphate phosphatase (SKIP) negatively regulates myogenesis through inhibition of IGF-II production and attenuation of the IGF-II-Akt-mTOR signaling pathway. We also demonstrate that SKIP expression, which was markedly elevated during differentiation, was controlled by MyoD in C2C12 cells. Expression of SKIP inhibited IGF-II at the transcription level. These results indicate that SKIP regulates MyoD-mediated muscle differentiation. Silencing of SKIP increased IGF-II transcription and myoblast differentiation. Furthermore, knockdown of SKIP resulted in thick myotubes with a larger number of nuclei than that in control C2C12 cells. Taken together, these data indicate that SKIP controls the IGF-II-PI 3-kinase-Akt-mTOR auto-regulation loop during myogenesis. Our findings identify SKIP as a key regulator of muscle cell differentiation."xsd:string |
| http://purl.uniprot.org/citations/22815484 | http://purl.org/dc/terms/identifier | "doi:10.1074/jbc.m112.388785"xsd:string |
| http://purl.uniprot.org/citations/22815484 | http://purl.uniprot.org/core/author | "Takenawa T."xsd:string |
| http://purl.uniprot.org/citations/22815484 | http://purl.uniprot.org/core/author | "Ijuin T."xsd:string |
| http://purl.uniprot.org/citations/22815484 | http://purl.uniprot.org/core/date | "2012"xsd:gYear |
| http://purl.uniprot.org/citations/22815484 | http://purl.uniprot.org/core/name | "J Biol Chem"xsd:string |
| http://purl.uniprot.org/citations/22815484 | http://purl.uniprot.org/core/pages | "31330-31341"xsd:string |
| http://purl.uniprot.org/citations/22815484 | http://purl.uniprot.org/core/title | "Role of phosphatidylinositol 3,4,5-trisphosphate (PIP3) 5-phosphatase skeletal muscle- and kidney-enriched inositol polyphosphate phosphatase (SKIP) in myoblast differentiation."xsd:string |
| http://purl.uniprot.org/citations/22815484 | http://purl.uniprot.org/core/volume | "287"xsd:string |
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| http://purl.uniprot.org/uniprot/#_B7Z8U3-mappedCitation-22815484 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/22815484 |
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