| http://purl.uniprot.org/citations/22817985 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/22817985 | http://www.w3.org/2000/01/rdf-schema#comment | "The Helicobacter pylori type IV secretion effector CagA is a major bacterial virulence determinant and critical for gastric carcinogenesis. Upon delivery into gastric epithelial cells, CagA localizes to the inner face of the plasma membrane, where it acts as a pathogenic scaffold/hub that promiscuously recruits host proteins to potentiate oncogenic signaling. We find that CagA comprises a structured N-terminal region and an intrinsically disordered C-terminal region that directs versatile protein interactions. X-ray crystallographic analysis of the N-terminal CagA fragment (residues 1-876) revealed that the region has a structure comprised of three discrete domains. Domain I constitutes a mobile CagA N terminus, while Domain II tethers CagA to the plasma membrane by interacting with membrane phosphatidylserine. Domain III interacts intramolecularly with the intrinsically disordered C-terminal region, and this interaction potentiates the pathogenic scaffold/hub function of CagA. The present work provides a tertiary-structural basis for the pathophysiological/oncogenic action of H. pylori CagA."xsd:string |
| http://purl.uniprot.org/citations/22817985 | http://purl.org/dc/terms/identifier | "doi:10.1016/j.chom.2012.05.010"xsd:string |
| http://purl.uniprot.org/citations/22817985 | http://purl.uniprot.org/core/author | "Hayashi T."xsd:string |
| http://purl.uniprot.org/citations/22817985 | http://purl.uniprot.org/core/author | "Inagaki F."xsd:string |
| http://purl.uniprot.org/citations/22817985 | http://purl.uniprot.org/core/author | "Senda T."xsd:string |
| http://purl.uniprot.org/citations/22817985 | http://purl.uniprot.org/core/author | "Shimizu T."xsd:string |
| http://purl.uniprot.org/citations/22817985 | http://purl.uniprot.org/core/author | "Senda M."xsd:string |
| http://purl.uniprot.org/citations/22817985 | http://purl.uniprot.org/core/author | "Noda N.N."xsd:string |
| http://purl.uniprot.org/citations/22817985 | http://purl.uniprot.org/core/author | "Kumeta H."xsd:string |
| http://purl.uniprot.org/citations/22817985 | http://purl.uniprot.org/core/author | "Morohashi H."xsd:string |
| http://purl.uniprot.org/citations/22817985 | http://purl.uniprot.org/core/author | "Hatakeyama M."xsd:string |
| http://purl.uniprot.org/citations/22817985 | http://purl.uniprot.org/core/author | "Higashi H."xsd:string |
| http://purl.uniprot.org/citations/22817985 | http://purl.uniprot.org/core/author | "Venugopalan N."xsd:string |
| http://purl.uniprot.org/citations/22817985 | http://purl.uniprot.org/core/author | "Horio M."xsd:string |
| http://purl.uniprot.org/citations/22817985 | http://purl.uniprot.org/core/author | "Kashiba Y."xsd:string |
| http://purl.uniprot.org/citations/22817985 | http://purl.uniprot.org/core/author | "Nagase L."xsd:string |
| http://purl.uniprot.org/citations/22817985 | http://purl.uniprot.org/core/author | "Sasaya D."xsd:string |
| http://purl.uniprot.org/citations/22817985 | http://purl.uniprot.org/core/date | "2012"xsd:gYear |
| http://purl.uniprot.org/citations/22817985 | http://purl.uniprot.org/core/name | "Cell Host Microbe"xsd:string |
| http://purl.uniprot.org/citations/22817985 | http://purl.uniprot.org/core/pages | "20-33"xsd:string |
| http://purl.uniprot.org/citations/22817985 | http://purl.uniprot.org/core/title | "Tertiary structure-function analysis reveals the pathogenic signaling potentiation mechanism of Helicobacter pylori oncogenic effector CagA."xsd:string |
| http://purl.uniprot.org/citations/22817985 | http://purl.uniprot.org/core/volume | "12"xsd:string |
| http://purl.uniprot.org/citations/22817985 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/22817985 |
| http://purl.uniprot.org/citations/22817985 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/22817985 |