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http://purl.uniprot.org/citations/22818943http://www.w3.org/1999/02/22-rdf-syntax-ns#typehttp://purl.uniprot.org/core/Journal_Citation
http://purl.uniprot.org/citations/22818943http://www.w3.org/2000/01/rdf-schema#comment"

Purpose

Oxcarbazepine (OXC) is a promising alternative for patients who cannot tolerate carbamazepine. Recently, however, it has been reported that OXC-induced cutaneous adverse drug reactions (cADRs) are prevalent and may lead to drug discontinuation. Additionally, these reactions are thought to be associated with HLA-B*1502. This study aims to investigate the incidence, features and risk factors of OXC-cADRs, and to explore their relation to HLA-B alleles in Southern Han Chinese.

Methods

A prospective study was performed to investigate the incidence, features and risk factors of OXC-cADRs, in which 252 new users were recruited. To examine the association between OXC-cADRs and HLA-B alleles, 14 maculopapular eruption (MPE) cases, including 9 additional cases beyond this prospective observation, were genotyped by PCR-SSP and sequencing. Thirty-five OXC-tolerant patients served as controls.

Results

Five patients (2.0%) developed an OXC-cADR, and all were mild MPE. History of other AED allergy (p=0.005, OR=121.23) and non-AED allergy (p=0.006, OR=59.92) were significant risk factors for OXC-cADRs in multivariate logistic regression analysis. Only one patient with OXC-MPE was positive for HLA-B*1502; and the frequency of HLA-B*1502 in OXC-MPE did not differ significantly from that in OXC-tolerant controls. Four HLA-B*1302 alleles were detected in OXC-MPE cases, which was significantly different from that in general population of southern Han Chinese (p=0.001, OR=7.83).

Conclusions

The incidence of OXC-induced cADRs was low, and no severe reactions occurred. Patients with a history of allergy are more susceptible to OXC-cADRs. No significant association between HLA-B*1502 and OXC-MPE was found. The associations between OXC-MPE and HLA alleles warrant further studies."xsd:string
http://purl.uniprot.org/citations/22818943http://purl.org/dc/terms/identifier"doi:10.1016/j.seizure.2012.06.014"xsd:string
http://purl.uniprot.org/citations/22818943http://purl.uniprot.org/core/author"He N."xsd:string
http://purl.uniprot.org/citations/22818943http://purl.uniprot.org/core/author"Guo J."xsd:string
http://purl.uniprot.org/citations/22818943http://purl.uniprot.org/core/author"Shi Y.W."xsd:string
http://purl.uniprot.org/citations/22818943http://purl.uniprot.org/core/author"Liu X.R."xsd:string
http://purl.uniprot.org/citations/22818943http://purl.uniprot.org/core/author"Zhou J.H."xsd:string
http://purl.uniprot.org/citations/22818943http://purl.uniprot.org/core/author"Liao W.P."xsd:string
http://purl.uniprot.org/citations/22818943http://purl.uniprot.org/core/author"Li B.M."xsd:string
http://purl.uniprot.org/citations/22818943http://purl.uniprot.org/core/author"Liao J.X."xsd:string
http://purl.uniprot.org/citations/22818943http://purl.uniprot.org/core/author"Min F.L."xsd:string
http://purl.uniprot.org/citations/22818943http://purl.uniprot.org/core/author"Ou Y.M."xsd:string
http://purl.uniprot.org/citations/22818943http://purl.uniprot.org/core/date"2012"xsd:gYear
http://purl.uniprot.org/citations/22818943http://purl.uniprot.org/core/name"Seizure"xsd:string
http://purl.uniprot.org/citations/22818943http://purl.uniprot.org/core/pages"614-618"xsd:string
http://purl.uniprot.org/citations/22818943http://purl.uniprot.org/core/title"Cutaneous reactions induced by oxcarbazepine in Southern Han Chinese: incidence, features, risk factors and relation to HLA-B alleles."xsd:string
http://purl.uniprot.org/citations/22818943http://purl.uniprot.org/core/volume"21"xsd:string
http://purl.uniprot.org/citations/22818943http://www.w3.org/2004/02/skos/core#exactMatchhttp://purl.uniprot.org/pubmed/22818943
http://purl.uniprot.org/citations/22818943http://xmlns.com/foaf/0.1/primaryTopicOfhttps://pubmed.ncbi.nlm.nih.gov/22818943
http://purl.uniprot.org/uniprot/#_A0A0A7C552-mappedCitation-22818943http://www.w3.org/1999/02/22-rdf-syntax-ns#objecthttp://purl.uniprot.org/citations/22818943
http://purl.uniprot.org/uniprot/#_A0A0E3DC98-mappedCitation-22818943http://www.w3.org/1999/02/22-rdf-syntax-ns#objecthttp://purl.uniprot.org/citations/22818943
http://purl.uniprot.org/uniprot/#_A0A0E3DCA0-mappedCitation-22818943http://www.w3.org/1999/02/22-rdf-syntax-ns#objecthttp://purl.uniprot.org/citations/22818943
http://purl.uniprot.org/uniprot/#_A0A0E3DCA1-mappedCitation-22818943http://www.w3.org/1999/02/22-rdf-syntax-ns#objecthttp://purl.uniprot.org/citations/22818943
http://purl.uniprot.org/uniprot/#_A0A068B107-mappedCitation-22818943http://www.w3.org/1999/02/22-rdf-syntax-ns#objecthttp://purl.uniprot.org/citations/22818943
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