| http://purl.uniprot.org/citations/22819533 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/22819533 | http://www.w3.org/2000/01/rdf-schema#comment | "Fibrinogen (Fg) is significantly up-regulated in the kidney after acute kidney injury (AKI). We evaluated the performance of Fg as a biomarker for early detection of AKI. In rats and mice with kidney tubular damage induced by ischemia/reperfusion (I/R) or cisplatin administration, respectively; kidney tissue and urinary Fg increased significantly and correlated with histopathological injury, urinary kidney injury molecule-1 (KIM-1) and N-acetyl glucosaminidase (NAG) corresponding to the progression and regression of injury temporally. In a longitudinal follow-up of 31 patients who underwent surgical repair of abdominal aortic aneurysm, urinary Fg increased earlier than SCr in patients who developed postoperative AKI (AUC-ROC = 0.72). Furthermore, in a cohort of patients with biopsy-proven AKI (n = 53), Fg immunoreactivity in the tubules and interstitium increased remarkably and was able to distinguish patients with AKI from those without AKI (n = 59). These results suggest that immunoreactivity of Fg in the kidney, as well as urinary excretion of Fg, serves as a sensitive and early diagnostic translational biomarker for detection of AKI."xsd:string |
| http://purl.uniprot.org/citations/22819533 | http://purl.org/dc/terms/identifier | "doi:10.1016/j.ajpath.2012.06.004"xsd:string |
| http://purl.uniprot.org/citations/22819533 | http://purl.uniprot.org/core/author | "Zhang Q."xsd:string |
| http://purl.uniprot.org/citations/22819533 | http://purl.uniprot.org/core/author | "Hoffmann D."xsd:string |
| http://purl.uniprot.org/citations/22819533 | http://purl.uniprot.org/core/author | "Brown R.P."xsd:string |
| http://purl.uniprot.org/citations/22819533 | http://purl.uniprot.org/core/author | "Krishnamoorthy A."xsd:string |
| http://purl.uniprot.org/citations/22819533 | http://purl.uniprot.org/core/author | "Bijol V."xsd:string |
| http://purl.uniprot.org/citations/22819533 | http://purl.uniprot.org/core/author | "Goering P.L."xsd:string |
| http://purl.uniprot.org/citations/22819533 | http://purl.uniprot.org/core/author | "Vaidya V.S."xsd:string |
| http://purl.uniprot.org/citations/22819533 | http://purl.uniprot.org/core/author | "Waikar S.S."xsd:string |
| http://purl.uniprot.org/citations/22819533 | http://purl.uniprot.org/core/author | "Frendl G."xsd:string |
| http://purl.uniprot.org/citations/22819533 | http://purl.uniprot.org/core/author | "Gonzalez V.R."xsd:string |
| http://purl.uniprot.org/citations/22819533 | http://purl.uniprot.org/core/date | "2012"xsd:gYear |
| http://purl.uniprot.org/citations/22819533 | http://purl.uniprot.org/core/name | "Am J Pathol"xsd:string |
| http://purl.uniprot.org/citations/22819533 | http://purl.uniprot.org/core/pages | "818-828"xsd:string |
| http://purl.uniprot.org/citations/22819533 | http://purl.uniprot.org/core/title | "Fibrinogen excretion in the urine and immunoreactivity in the kidney serves as a translational biomarker for acute kidney injury."xsd:string |
| http://purl.uniprot.org/citations/22819533 | http://purl.uniprot.org/core/volume | "181"xsd:string |
| http://purl.uniprot.org/citations/22819533 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/22819533 |
| http://purl.uniprot.org/citations/22819533 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/22819533 |
| http://purl.uniprot.org/uniprot/#_A1L114-mappedCitation-22819533 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/22819533 |
| http://purl.uniprot.org/uniprot/#_A0A0S2Z3M3-mappedCitation-22819533 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/22819533 |
| http://purl.uniprot.org/uniprot/#_A0A0S2Z3P3-mappedCitation-22819533 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/22819533 |
| http://purl.uniprot.org/uniprot/#_A0A0S2Z3E8-mappedCitation-22819533 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/22819533 |
| http://purl.uniprot.org/uniprot/#_A0A0S2Z3E9-mappedCitation-22819533 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/22819533 |