| http://purl.uniprot.org/citations/22819539 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/22819539 | http://www.w3.org/2000/01/rdf-schema#comment | "Systemic infections with Gram-negative bacteria are characterized by high mortality rates due to the "sepsis syndrome," a widespread and uncontrolled inflammatory response. Though it is well recognized that the immune response during Gram-negative bacterial infection is initiated after the recognition of endotoxin by Toll-like receptor 4, the molecular mechanisms underlying the detrimental inflammatory response during Gram-negative bacteremia remain poorly defined. Here, we identify a TRIF pathway that licenses NLRP3 inflammasome activation by all Gram-negative bacteria. By engaging TRIF, Gram-negative bacteria activate caspase-11. TRIF activates caspase-11 via type I IFN signaling, an event that is both necessary and sufficient for caspase-11 induction and autoactivation. Caspase-11 subsequently synergizes with the assembled NLRP3 inflammasome to regulate caspase-1 activation and leads to caspase-1-independent cell death. These events occur specifically during infection with Gram-negative, but not Gram-positive, bacteria. The identification of TRIF as a regulator of caspase-11 underscores the importance of TLRs as master regulators of inflammasomes during Gram-negative bacterial infection."xsd:string |
| http://purl.uniprot.org/citations/22819539 | http://purl.org/dc/terms/identifier | "doi:10.1016/j.cell.2012.07.007"xsd:string |
| http://purl.uniprot.org/citations/22819539 | http://purl.uniprot.org/core/author | "Leong J.M."xsd:string |
| http://purl.uniprot.org/citations/22819539 | http://purl.uniprot.org/core/author | "Becker C."xsd:string |
| http://purl.uniprot.org/citations/22819539 | http://purl.uniprot.org/core/author | "Fitzgerald K.A."xsd:string |
| http://purl.uniprot.org/citations/22819539 | http://purl.uniprot.org/core/author | "Rathinam V.A."xsd:string |
| http://purl.uniprot.org/citations/22819539 | http://purl.uniprot.org/core/author | "Vanaja S.K."xsd:string |
| http://purl.uniprot.org/citations/22819539 | http://purl.uniprot.org/core/author | "Waggoner L."xsd:string |
| http://purl.uniprot.org/citations/22819539 | http://purl.uniprot.org/core/author | "Stuart L.M."xsd:string |
| http://purl.uniprot.org/citations/22819539 | http://purl.uniprot.org/core/author | "Sokolovska A."xsd:string |
| http://purl.uniprot.org/citations/22819539 | http://purl.uniprot.org/core/date | "2012"xsd:gYear |
| http://purl.uniprot.org/citations/22819539 | http://purl.uniprot.org/core/name | "Cell"xsd:string |
| http://purl.uniprot.org/citations/22819539 | http://purl.uniprot.org/core/pages | "606-619"xsd:string |
| http://purl.uniprot.org/citations/22819539 | http://purl.uniprot.org/core/title | "TRIF licenses caspase-11-dependent NLRP3 inflammasome activation by gram-negative bacteria."xsd:string |
| http://purl.uniprot.org/citations/22819539 | http://purl.uniprot.org/core/volume | "150"xsd:string |
| http://purl.uniprot.org/citations/22819539 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/22819539 |
| http://purl.uniprot.org/citations/22819539 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/22819539 |
| http://purl.uniprot.org/uniprot/#_A0A125R9I3-mappedCitation-22819539 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/22819539 |
| http://purl.uniprot.org/uniprot/#_A0A087WQT6-mappedCitation-22819539 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/22819539 |
| http://purl.uniprot.org/uniprot/#_E0CY92-mappedCitation-22819539 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/22819539 |
| http://purl.uniprot.org/uniprot/#_E9PZP3-mappedCitation-22819539 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/22819539 |
| http://purl.uniprot.org/uniprot/#_A0A2R3XZC4-mappedCitation-22819539 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/22819539 |
| http://purl.uniprot.org/uniprot/#_A0A494B980-mappedCitation-22819539 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/22819539 |
| http://purl.uniprot.org/uniprot/#_A0A494B9A3-mappedCitation-22819539 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/22819539 |