| http://purl.uniprot.org/citations/22819675 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/22819675 | http://www.w3.org/2000/01/rdf-schema#comment | "During embryonic development tissues remain malleable to participate in morphogenetic movements but on completion of morphogenesis they must acquire the toughness essential for independent adult life. Desmosomes are cell-cell junctions that maintain tissue integrity especially where resistance to mechanical stress is required. Desmosomes in adult tissues are termed hyper-adhesive because they adhere strongly and are experimentally resistant to extracellular calcium chelation. Wounding results in weakening of desmosomal adhesion to a calcium-dependent state, presumably to facilitate cell migration and wound closure. Since desmosomes appear early in mouse tissue development we hypothesised that initial weak adhesion would be followed by acquisition of hyper-adhesion, the opposite of what happens on wounding. We show that epidermal desmosomes are calcium-dependent until embryonic day 12 (E12) and become hyper-adhesive by E14. Similarly, trophectodermal desmosomes change from calcium-dependence to hyper-adhesiveness as blastocyst development proceeds from E3 to E4.5. In both, development of hyper-adhesion is accompanied by the appearance of a midline between the plasma membranes supporting previous evidence that hyper-adhesiveness depends on the organised arrangement of desmosomal cadherins. By contrast, adherens junctions remain calcium-dependent throughout but tight junctions become calcium-independent as desmosomes mature. Using protein kinase C (PKC) activation and PKCα-/-mice, we provide evidence suggesting that conventional PKC isoforms are involved in developmental progression to hyper-adhesiveness. We demonstrate that modulation of desmosomal adhesion by PKC can regulate migration of trophectoderm. It appears that tissue stabilisation is one of several roles played by desmosomes in animal development."xsd:string |
| http://purl.uniprot.org/citations/22819675 | http://purl.org/dc/terms/identifier | "doi:10.1016/j.ydbio.2012.06.025"xsd:string |
| http://purl.uniprot.org/citations/22819675 | http://purl.uniprot.org/core/author | "Eckert J.J."xsd:string |
| http://purl.uniprot.org/citations/22819675 | http://purl.uniprot.org/core/author | "Fleming T.P."xsd:string |
| http://purl.uniprot.org/citations/22819675 | http://purl.uniprot.org/core/author | "Garrod D.R."xsd:string |
| http://purl.uniprot.org/citations/22819675 | http://purl.uniprot.org/core/author | "Kimura T.E."xsd:string |
| http://purl.uniprot.org/citations/22819675 | http://purl.uniprot.org/core/author | "Merritt A.J."xsd:string |
| http://purl.uniprot.org/citations/22819675 | http://purl.uniprot.org/core/author | "Lock F.R."xsd:string |
| http://purl.uniprot.org/citations/22819675 | http://purl.uniprot.org/core/date | "2012"xsd:gYear |
| http://purl.uniprot.org/citations/22819675 | http://purl.uniprot.org/core/name | "Dev Biol"xsd:string |
| http://purl.uniprot.org/citations/22819675 | http://purl.uniprot.org/core/pages | "286-297"xsd:string |
| http://purl.uniprot.org/citations/22819675 | http://purl.uniprot.org/core/title | "Desmosomal adhesiveness is developmentally regulated in the mouse embryo and modulated during trophectoderm migration."xsd:string |
| http://purl.uniprot.org/citations/22819675 | http://purl.uniprot.org/core/volume | "369"xsd:string |
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