| http://purl.uniprot.org/citations/22819818 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/22819818 | http://www.w3.org/2000/01/rdf-schema#comment | "The precise mechanism of how TNF-α promotes osteoclast formation is not clear. Previous reports show TNF-α targets molecules that regulate calcium signaling. Inositol-1,4,5-trisphosphate receptors (IP3Rs) are important calcium channel responsible for evoking intracellular calcium oscillation. We found that TNF-α increased the expression of IP3R1 and promoted osteoclastogenesis in RANKL-induced mouse BMMs. Phosphatidylcholine-specific phospholipase C (PC-PLC) specific inhibitor D609 eliminated the upregulation of IP3R1 by TNF-α, and decreased the autoamplification of nuclear factor of activated T-cells 1 (NFATc1), thus resulted in less osteoclasts formation. However, D609 did not inhibit RANKL-induced osteoclastogenesis. Our data suggest TNF-α promotes RANKL-induced osteoclastogenesis, at least partially, through PC-PLC/IP3R1/NFATc1 pathway."xsd:string |
| http://purl.uniprot.org/citations/22819818 | http://purl.org/dc/terms/identifier | "doi:10.1016/j.febslet.2012.07.015"xsd:string |
| http://purl.uniprot.org/citations/22819818 | http://purl.uniprot.org/core/author | "Hu Y."xsd:string |
| http://purl.uniprot.org/citations/22819818 | http://purl.uniprot.org/core/author | "Wang C."xsd:string |
| http://purl.uniprot.org/citations/22819818 | http://purl.uniprot.org/core/author | "Wei F."xsd:string |
| http://purl.uniprot.org/citations/22819818 | http://purl.uniprot.org/core/author | "Zhang D."xsd:string |
| http://purl.uniprot.org/citations/22819818 | http://purl.uniprot.org/core/author | "Xia L."xsd:string |
| http://purl.uniprot.org/citations/22819818 | http://purl.uniprot.org/core/date | "2012"xsd:gYear |
| http://purl.uniprot.org/citations/22819818 | http://purl.uniprot.org/core/name | "FEBS Lett"xsd:string |
| http://purl.uniprot.org/citations/22819818 | http://purl.uniprot.org/core/pages | "3341-3348"xsd:string |
| http://purl.uniprot.org/citations/22819818 | http://purl.uniprot.org/core/title | "PC-PLC is involved in osteoclastogenesis induced by TNF-alpha through upregulating IP3R1 expression."xsd:string |
| http://purl.uniprot.org/citations/22819818 | http://purl.uniprot.org/core/volume | "586"xsd:string |
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