| http://purl.uniprot.org/citations/22819829 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/22819829 | http://www.w3.org/2000/01/rdf-schema#comment | "Here we show that tyrosine phosphorylation of caveolin-2 (Cav-2) negatively regulates the anti-proliferative function of transforming growth factor beta (TGF-beta) in endothelial cells. In contrast to wild-type-Cav-2, retroviral re-expression of Y19/27F-Cav-2 in Cav-2 knockout endothelial cells did not affect anti-proliferative effect of TGF-beta compared to empty vector. Conversely, although less effective than wild-type, re-expression of S23/36A-Cav-2 reduced the effect of TGF-beta compared to empty vector. This differential effect of tyrosine and serine phosphorylation mutants of Cav-2 correlated with TGF-beta-induced Smad3 phosphorylation and transcriptional activation of plasminogen activator inhibitor-1. Thus tyrosine-phosphorylated Cav-2 counteracts anti-proliferative effect of TGF-beta in endothelial cells."xsd:string |
| http://purl.uniprot.org/citations/22819829 | http://purl.org/dc/terms/identifier | "doi:10.1016/j.febslet.2012.07.008"xsd:string |
| http://purl.uniprot.org/citations/22819829 | http://purl.uniprot.org/core/author | "Xie L."xsd:string |
| http://purl.uniprot.org/citations/22819829 | http://purl.uniprot.org/core/author | "Jang S."xsd:string |
| http://purl.uniprot.org/citations/22819829 | http://purl.uniprot.org/core/author | "Cooper L."xsd:string |
| http://purl.uniprot.org/citations/22819829 | http://purl.uniprot.org/core/author | "Sowa G."xsd:string |
| http://purl.uniprot.org/citations/22819829 | http://purl.uniprot.org/core/author | "Abel B."xsd:string |
| http://purl.uniprot.org/citations/22819829 | http://purl.uniprot.org/core/author | "Willoughby C."xsd:string |
| http://purl.uniprot.org/citations/22819829 | http://purl.uniprot.org/core/author | "Vo-Ransdell C."xsd:string |
| http://purl.uniprot.org/citations/22819829 | http://purl.uniprot.org/core/date | "2012"xsd:gYear |
| http://purl.uniprot.org/citations/22819829 | http://purl.uniprot.org/core/name | "FEBS Lett"xsd:string |
| http://purl.uniprot.org/citations/22819829 | http://purl.uniprot.org/core/pages | "3317-3323"xsd:string |
| http://purl.uniprot.org/citations/22819829 | http://purl.uniprot.org/core/title | "N-terminal tyrosine phosphorylation of caveolin-2 negates anti-proliferative effect of transforming growth factor beta in endothelial cells."xsd:string |
| http://purl.uniprot.org/citations/22819829 | http://purl.uniprot.org/core/volume | "586"xsd:string |
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| http://purl.uniprot.org/citations/22819829 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/22819829 |
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