| http://purl.uniprot.org/citations/22821967 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/22821967 | http://www.w3.org/2000/01/rdf-schema#comment | "Cyclic di-GMP (c-di-GMP) is a second messenger that regulates diverse cellular processes in bacteria, including motility, biofilm formation, cell-cell signaling, and host colonization. Studies of c-di-GMP signaling have chiefly focused on Gram-negative bacteria. Here, we investigated c-di-GMP signaling in the Gram-positive bacterium Bacillus subtilis by constructing deletion mutations in genes predicted to be involved in the synthesis, breakdown, or response to the second messenger. We found that a putative c-di-GMP-degrading phosphodiesterase, YuxH, and a putative c-di-GMP receptor, YpfA, had strong influences on motility and that these effects depended on sequences similar to canonical EAL and RxxxR-D/NxSxxG motifs, respectively. Evidence indicates that YpfA inhibits motility by interacting with the flagellar motor protein MotA and that yuxH is under the negative control of the master regulator Spo0A∼P. Based on these findings, we propose that YpfA inhibits motility in response to rising levels of c-di-GMP during entry into stationary phase due to the downregulation of yuxH by Spo0A∼P. We also present evidence that YpfA has a mild influence on biofilm formation. In toto, our results demonstrate the existence of a functional c-di-GMP signaling system in B. subtilis that directly inhibits motility and directly or indirectly influences biofilm formation."xsd:string |
| http://purl.uniprot.org/citations/22821967 | http://purl.org/dc/terms/identifier | "doi:10.1128/jb.01092-12"xsd:string |
| http://purl.uniprot.org/citations/22821967 | http://purl.uniprot.org/core/author | "Chen Y."xsd:string |
| http://purl.uniprot.org/citations/22821967 | http://purl.uniprot.org/core/author | "Losick R."xsd:string |
| http://purl.uniprot.org/citations/22821967 | http://purl.uniprot.org/core/author | "Chai Y."xsd:string |
| http://purl.uniprot.org/citations/22821967 | http://purl.uniprot.org/core/author | "Guo J.H."xsd:string |
| http://purl.uniprot.org/citations/22821967 | http://purl.uniprot.org/core/date | "2012"xsd:gYear |
| http://purl.uniprot.org/citations/22821967 | http://purl.uniprot.org/core/name | "J Bacteriol"xsd:string |
| http://purl.uniprot.org/citations/22821967 | http://purl.uniprot.org/core/pages | "5080-5090"xsd:string |
| http://purl.uniprot.org/citations/22821967 | http://purl.uniprot.org/core/title | "Evidence for cyclic Di-GMP-mediated signaling in Bacillus subtilis."xsd:string |
| http://purl.uniprot.org/citations/22821967 | http://purl.uniprot.org/core/volume | "194"xsd:string |
| http://purl.uniprot.org/citations/22821967 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/22821967 |
| http://purl.uniprot.org/citations/22821967 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/22821967 |
| http://purl.uniprot.org/uniprot/#_P38491-mappedCitation-22821967 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/22821967 |
| http://purl.uniprot.org/uniprot/#_P27206-mappedCitation-22821967 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/22821967 |
| http://purl.uniprot.org/uniprot/#_Q04747-mappedCitation-22821967 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/22821967 |
| http://purl.uniprot.org/uniprot/#_P28611-mappedCitation-22821967 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/22821967 |
| http://purl.uniprot.org/uniprot/#_P28612-mappedCitation-22821967 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/22821967 |
| http://purl.uniprot.org/uniprot/#_Q08787-mappedCitation-22821967 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/22821967 |
| http://purl.uniprot.org/uniprot/P27206 | http://purl.uniprot.org/core/mappedCitation | http://purl.uniprot.org/citations/22821967 |
| http://purl.uniprot.org/uniprot/Q04747 | http://purl.uniprot.org/core/mappedCitation | http://purl.uniprot.org/citations/22821967 |
| http://purl.uniprot.org/uniprot/Q08787 | http://purl.uniprot.org/core/mappedCitation | http://purl.uniprot.org/citations/22821967 |
| http://purl.uniprot.org/uniprot/P28612 | http://purl.uniprot.org/core/mappedCitation | http://purl.uniprot.org/citations/22821967 |
| http://purl.uniprot.org/uniprot/P38491 | http://purl.uniprot.org/core/mappedCitation | http://purl.uniprot.org/citations/22821967 |