| http://purl.uniprot.org/citations/22825724 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/22825724 | http://www.w3.org/2000/01/rdf-schema#comment | "Oligodendroglial tumors (ODTs) are primary tumors of the central nervous system that show recurrent codeletion of whole chromosome arms 1p and 19q. Non-1p/19q-deleted high-grade ODTs can present other genetic aberrations, CDKN2A deletion (9p21.3), EGFR amplification (7p11.2) and/or chromosome 10 loss, which are associated with a poor prognosis. The identification of these abnormalities allowed drafting a histo-molecular classification. The aim of this study was to precisely identify, using array CGH, the genomic hallmarks of these tumors, particularly those that are not deleted on 1p/19q. We studied 14 formalin-fixed paraffin-embedded high-grade ODTs using pangenomic oligonucleotide array CGH with an average resolution of 22.3 kb. The 1p/19q codeletion was found in five anaplastic oligodendrogliomas. The three genomic aberrations carrying a poor prognosis were found, most often associated, in five out of nine tumors not deleted on 1p/19q. In addition, four recurrent copy number alterations, involving genes that participate to cell growth and cycle, were found to be strongly associated in five tumors not deleted on 1p/19q: gain or amplification at 1q32.1 (MDM4, PIK3C2B genes), 12q14.1 (CDK4 gene), 12q14.3-q15 (MDM2 gene) and homozygous deletion at 22q13.1 (APOBEC3B gene). MDM2, MDM4, CDK4 and PIK3C2B are known for potentially being amplified or overexpressed in high-grade gliomas. However, the involvement of APOBEC3B, coding for mRNA edition enzyme, is described here for the first time. Our results show a strong association between these four alterations. Therefore, this can open a perspective for a novel subgroup in high-grade ODTs not deleted on 1p/19q."xsd:string |
| http://purl.uniprot.org/citations/22825724 | http://purl.org/dc/terms/identifier | "doi:10.1007/s11060-012-0909-1"xsd:string |
| http://purl.uniprot.org/citations/22825724 | http://purl.uniprot.org/core/author | "Morel F."xsd:string |
| http://purl.uniprot.org/citations/22825724 | http://purl.uniprot.org/core/author | "Ferec C."xsd:string |
| http://purl.uniprot.org/citations/22825724 | http://purl.uniprot.org/core/author | "Marcorelles P."xsd:string |
| http://purl.uniprot.org/citations/22825724 | http://purl.uniprot.org/core/author | "Costa S."xsd:string |
| http://purl.uniprot.org/citations/22825724 | http://purl.uniprot.org/core/author | "Redon S."xsd:string |
| http://purl.uniprot.org/citations/22825724 | http://purl.uniprot.org/core/author | "De Braekeleer M."xsd:string |
| http://purl.uniprot.org/citations/22825724 | http://purl.uniprot.org/core/author | "Hieu P.D."xsd:string |
| http://purl.uniprot.org/citations/22825724 | http://purl.uniprot.org/core/author | "Quintin-Roue I."xsd:string |
| http://purl.uniprot.org/citations/22825724 | http://purl.uniprot.org/core/author | "Talagas M."xsd:string |
| http://purl.uniprot.org/citations/22825724 | http://purl.uniprot.org/core/author | "Uguen A."xsd:string |
| http://purl.uniprot.org/citations/22825724 | http://purl.uniprot.org/core/date | "2012"xsd:gYear |
| http://purl.uniprot.org/citations/22825724 | http://purl.uniprot.org/core/name | "J Neurooncol"xsd:string |
| http://purl.uniprot.org/citations/22825724 | http://purl.uniprot.org/core/pages | "405-413"xsd:string |
| http://purl.uniprot.org/citations/22825724 | http://purl.uniprot.org/core/title | "Identification of a novel population in high-grade oligodendroglial tumors not deleted on 1p/19q using array CGH."xsd:string |
| http://purl.uniprot.org/citations/22825724 | http://purl.uniprot.org/core/volume | "109"xsd:string |
| http://purl.uniprot.org/citations/22825724 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/22825724 |
| http://purl.uniprot.org/citations/22825724 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/22825724 |
| http://purl.uniprot.org/uniprot/#_A0A087WTR9-mappedCitation-22825724 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/22825724 |
| http://purl.uniprot.org/uniprot/#_A0A087WUE3-mappedCitation-22825724 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/22825724 |
| http://purl.uniprot.org/uniprot/#_A0A087WZ58-mappedCitation-22825724 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/22825724 |
| http://purl.uniprot.org/uniprot/#_A2RUF7-mappedCitation-22825724 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/22825724 |
| http://purl.uniprot.org/uniprot/#_B4E122-mappedCitation-22825724 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/22825724 |