| http://purl.uniprot.org/citations/22826228 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/22826228 | http://www.w3.org/2000/01/rdf-schema#comment | "Human leukocyte antigen HLA-B alleles have better protective activity against HIV-1 than HLA-A alleles, possibly due to differences in HLA-restricted HIV-1-specific CD8+ cytotoxic T lymphocyte (CTL) function, but the mechanism is unknown. HIV-1 negative regulatory factor (Nef) mediates down-regulation of surface expression of class I HLA (HLA-I) and may therefore impair immune recognition by CTL. Because of sequence differences in the cytoplasmic domains, HLA-A and -B are down-regulated by Nef but HLA-C and -E are not affected. However, the latter are expressed at low levels and are not of major importance in the CTL responses to HIV-1. Here, we compared the role of the cytoplasmic domains of HLA-A and -B in Nef-mediated escape from CTL. We found HLA-B cytoplasmic domains were more resistant to Nef-mediated down-regulation than HLA-A cytoplasmic domains and demonstrated that these differences affect CTL recognition of virus-infected cells in vitro. We propose that the relative resistance to Nef-mediated down-regulation by the cytoplasmic domains of HLA-B compared with HLA-A contributes to the better control of HIV-1 infection associated with HLA-B-restricted CTLs."xsd:string |
| http://purl.uniprot.org/citations/22826228 | http://purl.org/dc/terms/identifier | "doi:10.1073/pnas.1204199109"xsd:string |
| http://purl.uniprot.org/citations/22826228 | http://purl.uniprot.org/core/author | "Li D."xsd:string |
| http://purl.uniprot.org/citations/22826228 | http://purl.uniprot.org/core/author | "McMichael A.J."xsd:string |
| http://purl.uniprot.org/citations/22826228 | http://purl.uniprot.org/core/author | "Peng Y.C."xsd:string |
| http://purl.uniprot.org/citations/22826228 | http://purl.uniprot.org/core/author | "Dong T."xsd:string |
| http://purl.uniprot.org/citations/22826228 | http://purl.uniprot.org/core/author | "Xu X.N."xsd:string |
| http://purl.uniprot.org/citations/22826228 | http://purl.uniprot.org/core/author | "Rajapaksa U.S."xsd:string |
| http://purl.uniprot.org/citations/22826228 | http://purl.uniprot.org/core/date | "2012"xsd:gYear |
| http://purl.uniprot.org/citations/22826228 | http://purl.uniprot.org/core/name | "Proc Natl Acad Sci U S A"xsd:string |
| http://purl.uniprot.org/citations/22826228 | http://purl.uniprot.org/core/pages | "13353-13358"xsd:string |
| http://purl.uniprot.org/citations/22826228 | http://purl.uniprot.org/core/title | "HLA-B may be more protective against HIV-1 than HLA-A because it resists negative regulatory factor (Nef) mediated down-regulation."xsd:string |
| http://purl.uniprot.org/citations/22826228 | http://purl.uniprot.org/core/volume | "109"xsd:string |
| http://purl.uniprot.org/citations/22826228 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/22826228 |
| http://purl.uniprot.org/citations/22826228 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/22826228 |
| http://purl.uniprot.org/uniprot/#_A0A0A7C543-mappedCitation-22826228 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/22826228 |
| http://purl.uniprot.org/uniprot/#_A0A0A7C548-mappedCitation-22826228 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/22826228 |
| http://purl.uniprot.org/uniprot/#_A0A0A7C551-mappedCitation-22826228 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/22826228 |
| http://purl.uniprot.org/uniprot/#_A0A0A7C552-mappedCitation-22826228 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/22826228 |
| http://purl.uniprot.org/uniprot/#_A0A0E3DC98-mappedCitation-22826228 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/22826228 |
| http://purl.uniprot.org/uniprot/#_A0A0E3DCA0-mappedCitation-22826228 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/22826228 |
| http://purl.uniprot.org/uniprot/#_A0A0E3DCA1-mappedCitation-22826228 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/22826228 |
| http://purl.uniprot.org/uniprot/#_A0A0G2R0N3-mappedCitation-22826228 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/22826228 |
| http://purl.uniprot.org/uniprot/#_A0A0G2R0N4-mappedCitation-22826228 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/22826228 |