| http://purl.uniprot.org/citations/22826299 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/22826299 | http://www.w3.org/2000/01/rdf-schema#comment | "When a cell undergoes apoptosis, phosphatidylserine (PS) is exposed on the outer leaflet of the plasma membrane. PS acts as an "eat-me" signal to direct phagocytes expressing PS receptors to engulf the apoptotic cell. We recently reported that the immunoreceptor CD300a, which is expressed on myeloid cells, is a PS receptor. We show that CD300a does not facilitate macrophage phagocytosis of apoptotic cells. Instead, CD300a delivers an inhibitory signal in mast cells to suppress production of LPS-induced inflammatory cytokines and chemokines. After cecal ligation and puncture (CLP), when a large number of cells undergo apoptosis in the peritoneal cavity, CD300a-deficient peritoneal mast cells produced more chemoattractant and recruited more neutrophils than did wild-type (WT) mast cells. As a result, CD300a-deficient mice showed increased neutrophil recruitment and improved bacterial clearance in the peritoneal cavity, and survived longer than WT mice. Antibody blockade of CD300a-PS interactions improved bacterial clearance and extended survival of WT mice subjected to CLP. These results indicated that CD300a is a nonphagocytic PS receptor that regulates mast cell inflammatory responses to microbial infections."xsd:string |
| http://purl.uniprot.org/citations/22826299 | http://purl.org/dc/terms/identifier | "doi:10.1084/jem.20120096"xsd:string |
| http://purl.uniprot.org/citations/22826299 | http://purl.uniprot.org/core/author | "Honda S."xsd:string |
| http://purl.uniprot.org/citations/22826299 | http://purl.uniprot.org/core/author | "Shibuya K."xsd:string |
| http://purl.uniprot.org/citations/22826299 | http://purl.uniprot.org/core/author | "Shoji M."xsd:string |
| http://purl.uniprot.org/citations/22826299 | http://purl.uniprot.org/core/author | "Nagata S."xsd:string |
| http://purl.uniprot.org/citations/22826299 | http://purl.uniprot.org/core/author | "Yasui T."xsd:string |
| http://purl.uniprot.org/citations/22826299 | http://purl.uniprot.org/core/author | "Shibuya A."xsd:string |
| http://purl.uniprot.org/citations/22826299 | http://purl.uniprot.org/core/author | "Tahara-Hanaoka S."xsd:string |
| http://purl.uniprot.org/citations/22826299 | http://purl.uniprot.org/core/author | "Nakahashi-Oda C."xsd:string |
| http://purl.uniprot.org/citations/22826299 | http://purl.uniprot.org/core/author | "Ohkohchi N."xsd:string |
| http://purl.uniprot.org/citations/22826299 | http://purl.uniprot.org/core/author | "Okoshi Y."xsd:string |
| http://purl.uniprot.org/citations/22826299 | http://purl.uniprot.org/core/author | "Kikutani H."xsd:string |
| http://purl.uniprot.org/citations/22826299 | http://purl.uniprot.org/core/author | "Nakano-Yokomizo T."xsd:string |
| http://purl.uniprot.org/citations/22826299 | http://purl.uniprot.org/core/date | "2012"xsd:gYear |
| http://purl.uniprot.org/citations/22826299 | http://purl.uniprot.org/core/name | "J Exp Med"xsd:string |
| http://purl.uniprot.org/citations/22826299 | http://purl.uniprot.org/core/pages | "1493-1503"xsd:string |
| http://purl.uniprot.org/citations/22826299 | http://purl.uniprot.org/core/title | "Apoptotic cells suppress mast cell inflammatory responses via the CD300a immunoreceptor."xsd:string |
| http://purl.uniprot.org/citations/22826299 | http://purl.uniprot.org/core/volume | "209"xsd:string |
| http://purl.uniprot.org/citations/22826299 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/22826299 |
| http://purl.uniprot.org/citations/22826299 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/22826299 |
| http://purl.uniprot.org/uniprot/#_A0A1W2P7L3-mappedCitation-22826299 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/22826299 |
| http://purl.uniprot.org/uniprot/#_A4ZVL1-mappedCitation-22826299 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/22826299 |
| http://purl.uniprot.org/uniprot/#_Q8BP66-mappedCitation-22826299 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/22826299 |