http://purl.uniprot.org/citations/22829643 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
http://purl.uniprot.org/citations/22829643 | http://www.w3.org/2000/01/rdf-schema#comment | "BackgroundEnterovirus 71 (EV71) causes large outbreaks of hand, foot, and mouth disease (HFMD), with severe neurological complications and cardio-respiratory compromise, but the pathogenesis is poorly understood.MethodsWe measured levels of 30 chemokines and cytokines in serum and cerebrospinal fluid (CSF) samples from Malaysian children hospitalized with EV71 infection (n = 88), comprising uncomplicated HFMD (n = 47), meningitis (n = 8), acute flaccid paralysis (n = 1), encephalitis (n = 21), and encephalitis with cardiorespiratory compromise (n = 11). Four of the latter patients died.ResultsBoth pro-inflammatory and anti-inflammatory mediator levels were elevated, with different patterns of mediator abundance in the CSF and vascular compartments. Serum concentrations of interleukin 1β (IL-1β), interleukin 1 receptor antagonist (IL-1Ra), and granulocyte colony-stimulating factor (G-CSF) were raised significantly in patients who developed cardio-respiratory compromise (P = .013, P = .004, and P < .001, respectively). Serum IL-1Ra and G-CSF levels were also significantly elevated in patients who died, with a serum G-CSF to interleukin 5 ratio of >100 at admission being the most accurate prognostic marker for death (P < .001; accuracy, 85.5%; sensitivity, 100%; specificity, 84.7%).ConclusionsGiven that IL-1β has a negative inotropic action on the heart, and that both its natural antagonist, IL-1Ra, and G-CSF are being assessed as treatments for acute cardiac impairment, the findings suggest we have identified functional markers of EV71-related cardiac dysfunction and potential treatment options."xsd:string |
http://purl.uniprot.org/citations/22829643 | http://purl.org/dc/terms/identifier | "doi:10.1093/infdis/jis446"xsd:string |
http://purl.uniprot.org/citations/22829643 | http://purl.uniprot.org/core/author | "Wong S.C."xsd:string |
http://purl.uniprot.org/citations/22829643 | http://purl.uniprot.org/core/author | "Mohan A."xsd:string |
http://purl.uniprot.org/citations/22829643 | http://purl.uniprot.org/core/author | "Perera D."xsd:string |
http://purl.uniprot.org/citations/22829643 | http://purl.uniprot.org/core/author | "Cardosa M.J."xsd:string |
http://purl.uniprot.org/citations/22829643 | http://purl.uniprot.org/core/author | "Griffiths M.J."xsd:string |
http://purl.uniprot.org/citations/22829643 | http://purl.uniprot.org/core/author | "Tio P.H."xsd:string |
http://purl.uniprot.org/citations/22829643 | http://purl.uniprot.org/core/author | "Podin Y."xsd:string |
http://purl.uniprot.org/citations/22829643 | http://purl.uniprot.org/core/author | "Ooi M.H."xsd:string |
http://purl.uniprot.org/citations/22829643 | http://purl.uniprot.org/core/author | "Solomon T."xsd:string |
http://purl.uniprot.org/citations/22829643 | http://purl.uniprot.org/core/author | "Chieng C.H."xsd:string |
http://purl.uniprot.org/citations/22829643 | http://purl.uniprot.org/core/date | "2012"xsd:gYear |
http://purl.uniprot.org/citations/22829643 | http://purl.uniprot.org/core/name | "J Infect Dis"xsd:string |
http://purl.uniprot.org/citations/22829643 | http://purl.uniprot.org/core/pages | "881-892"xsd:string |
http://purl.uniprot.org/citations/22829643 | http://purl.uniprot.org/core/title | "In enterovirus 71 encephalitis with cardio-respiratory compromise, elevated interleukin 1beta, interleukin 1 receptor antagonist, and granulocyte colony-stimulating factor levels are markers of poor prognosis."xsd:string |
http://purl.uniprot.org/citations/22829643 | http://purl.uniprot.org/core/volume | "206"xsd:string |
http://purl.uniprot.org/citations/22829643 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/22829643 |
http://purl.uniprot.org/citations/22829643 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/22829643 |
http://purl.uniprot.org/uniprot/#_A0A0B4U5E3-mappedCitation-22829643 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/22829643 |
http://purl.uniprot.org/uniprot/#_A0A510GAG5-mappedCitation-22829643 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/22829643 |
http://purl.uniprot.org/uniprot/#_C3VB11-mappedCitation-22829643 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/22829643 |
http://purl.uniprot.org/uniprot/#_A0AA51YZX7-mappedCitation-22829643 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/22829643 |
http://purl.uniprot.org/uniprot/#_B4DNY7-mappedCitation-22829643 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/22829643 |