| http://purl.uniprot.org/citations/22832121 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/22832121 | http://www.w3.org/2000/01/rdf-schema#comment | "Recruited host factors aid replication of plus-strand RNA viruses. In this paper, we show that Dbp2 DEAD-box helicase of yeast, which is a homolog of human p68 DEAD-box helicase, directly affects replication of Tomato bushy stunt virus (TBSV). We demonstrate that Dbp2 binds to the 3'-end of the viral minus-stranded RNA and enhances plus-strand synthesis by the viral replicase in a yeast-based cell-free TBSV replication assay. In vitro data with wt and an ATPase-deficient Dbp2 mutant indicate that Dbp2 unwinds local secondary structures at the 3'-end of the TBSV (-)RNA. We also show that Dbp2 complements the replication deficiency of TBSV in yeast containing reduced amount of Ded1 DEAD-box helicase, another host factor involved in TBSV replication, suggesting that Dbp2 and Ded1 helicases play redundant roles in TBSV replication. We also show that the orthologous AtRH20 DEAD-box helicase from Arabidopsis can increase tombusvirus replication in vitro and in yeast."xsd:string |
| http://purl.uniprot.org/citations/22832121 | http://purl.org/dc/terms/identifier | "doi:10.1016/j.virol.2012.06.030"xsd:string |
| http://purl.uniprot.org/citations/22832121 | http://purl.uniprot.org/core/author | "Barajas D."xsd:string |
| http://purl.uniprot.org/citations/22832121 | http://purl.uniprot.org/core/author | "Kovalev N."xsd:string |
| http://purl.uniprot.org/citations/22832121 | http://purl.uniprot.org/core/author | "Nagy P.D."xsd:string |
| http://purl.uniprot.org/citations/22832121 | http://purl.uniprot.org/core/date | "2012"xsd:gYear |
| http://purl.uniprot.org/citations/22832121 | http://purl.uniprot.org/core/name | "Virology"xsd:string |
| http://purl.uniprot.org/citations/22832121 | http://purl.uniprot.org/core/pages | "470-484"xsd:string |
| http://purl.uniprot.org/citations/22832121 | http://purl.uniprot.org/core/title | "Similar roles for yeast Dbp2 and Arabidopsis RH20 DEAD-box RNA helicases to Ded1 helicase in tombusvirus plus-strand synthesis."xsd:string |
| http://purl.uniprot.org/citations/22832121 | http://purl.uniprot.org/core/volume | "432"xsd:string |
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