| http://purl.uniprot.org/citations/22832515 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/22832515 | http://www.w3.org/2000/01/rdf-schema#comment | "Chronic serum sickness leads to the formation of glomerular immune complexes; however, C57BL/6 mice do not develop glomerulonephritis unless complement factor H (CFH) is absent from the plasma. Here we studied the role for C5a receptor (R) in this setting. The exaggerated humoral immune response in CFH(-/-) mice was normalized in CFH(-/-)C5aR(-/-) double knockout mice, highlighting the C5aR dependence. The CFH knockout mice developed proliferative glomerulonephritis with endocapillary F4/80+ macrophage infiltration, a process reduced in the double knockout mice. There was no interstitial inflammation by histologic criteria or flow cytometry for F4/80+ Ly6C(hi)CCR2(hi) inflammatory macrophages. There were, however, more interstitial CD3+ CD4+ T lymphocytes in CFH knockout mice with chronic serum sickness, while double knockout mice had greater than 5-fold more Ly6C(lo)CCR2(lo) anti-inflammatory macrophages compared to the CFH knockout mice. Mice lacking C5aR were significantly protected from functional renal disease as assessed by blood urea nitrogen levels. Thus, IgG- and iC3b-containing immune complexes are not inflammatory in C57BL/6 mice. Yet when these mice lack CFH, sufficient C3b persists in glomeruli to generate C5a and activate C5aR."xsd:string |
| http://purl.uniprot.org/citations/22832515 | http://purl.org/dc/terms/identifier | "doi:10.1038/ki.2012.249"xsd:string |
| http://purl.uniprot.org/citations/22832515 | http://purl.uniprot.org/core/author | "Chang A."xsd:string |
| http://purl.uniprot.org/citations/22832515 | http://purl.uniprot.org/core/author | "Alexander J.J."xsd:string |
| http://purl.uniprot.org/citations/22832515 | http://purl.uniprot.org/core/author | "Quigg R.J."xsd:string |
| http://purl.uniprot.org/citations/22832515 | http://purl.uniprot.org/core/author | "Chaves L."xsd:string |
| http://purl.uniprot.org/citations/22832515 | http://purl.uniprot.org/core/date | "2012"xsd:gYear |
| http://purl.uniprot.org/citations/22832515 | http://purl.uniprot.org/core/name | "Kidney Int"xsd:string |
| http://purl.uniprot.org/citations/22832515 | http://purl.uniprot.org/core/pages | "961-968"xsd:string |
| http://purl.uniprot.org/citations/22832515 | http://purl.uniprot.org/core/title | "The C5a receptor has a key role in immune complex glomerulonephritis in complement factor H-deficient mice."xsd:string |
| http://purl.uniprot.org/citations/22832515 | http://purl.uniprot.org/core/volume | "82"xsd:string |
| http://purl.uniprot.org/citations/22832515 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/22832515 |
| http://purl.uniprot.org/citations/22832515 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/22832515 |
| http://purl.uniprot.org/uniprot/#_A0A0A6YWP4-mappedCitation-22832515 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/22832515 |
| http://purl.uniprot.org/uniprot/#_A0A0A6YVP8-mappedCitation-22832515 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/22832515 |
| http://purl.uniprot.org/uniprot/#_A0A1B0GT01-mappedCitation-22832515 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/22832515 |
| http://purl.uniprot.org/uniprot/#_E9Q8H9-mappedCitation-22832515 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/22832515 |
| http://purl.uniprot.org/uniprot/#_E9Q8I0-mappedCitation-22832515 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/22832515 |
| http://purl.uniprot.org/uniprot/#_D6RGQ0-mappedCitation-22832515 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/22832515 |
| http://purl.uniprot.org/uniprot/#_P06909-mappedCitation-22832515 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/22832515 |
| http://purl.uniprot.org/uniprot/#_P30993-mappedCitation-22832515 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/22832515 |
| http://purl.uniprot.org/uniprot/#_Q3UCS9-mappedCitation-22832515 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/22832515 |
| http://purl.uniprot.org/uniprot/#_Q61848-mappedCitation-22832515 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/22832515 |
| http://purl.uniprot.org/uniprot/#_Q8C5S1-mappedCitation-22832515 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/22832515 |