| http://purl.uniprot.org/citations/22836248 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/22836248 | http://www.w3.org/2000/01/rdf-schema#comment | "Although the presynaptic protein α-synuclein is a recognized player in neurodegeneration, its precise physiologic function(s) and/or role in human disease remains unclear. An emerging consensus from previous studies in lower-order systems is that α-synuclein interferes with vesicle-trafficking pathways; however putative neuronal correlates are unknown. Here we explore consequences of α-synuclein modulation in cultured mouse hippocampal neurons; coupling α-synuclein overexpression and knock-out model-systems with contemporary imaging paradigms. Our studies reveal an unexpected role of α-synuclein in attenuating the mobility of recycling pool (RP) vesicles between presynaptic boutons--called "superpool" trafficking--and also in maintaining the overall size of RPs at synapses. While an excess of α-synuclein led to smaller RPs and inhibited intersynaptic trafficking, an absence of α-synuclein triggered converse changes with larger RPs and enhanced intersynaptic trafficking. The data collectively suggest a model where α-synuclein maintains RP homeostasis by modulating intersynaptic vesicular dynamics, and provide a putative neuronal correlate of α-synuclein-induced impairments in vesicle-trafficking previously reported in lower-order systems."xsd:string |
| http://purl.uniprot.org/citations/22836248 | http://purl.org/dc/terms/identifier | "doi:10.1523/jneurosci.0535-12.2012"xsd:string |
| http://purl.uniprot.org/citations/22836248 | http://purl.uniprot.org/core/author | "Scott D."xsd:string |
| http://purl.uniprot.org/citations/22836248 | http://purl.uniprot.org/core/author | "Roy S."xsd:string |
| http://purl.uniprot.org/citations/22836248 | http://purl.uniprot.org/core/date | "2012"xsd:gYear |
| http://purl.uniprot.org/citations/22836248 | http://purl.uniprot.org/core/name | "J Neurosci"xsd:string |
| http://purl.uniprot.org/citations/22836248 | http://purl.uniprot.org/core/pages | "10129-10135"xsd:string |
| http://purl.uniprot.org/citations/22836248 | http://purl.uniprot.org/core/title | "alpha-Synuclein inhibits intersynaptic vesicle mobility and maintains recycling-pool homeostasis."xsd:string |
| http://purl.uniprot.org/citations/22836248 | http://purl.uniprot.org/core/volume | "32"xsd:string |
| http://purl.uniprot.org/citations/22836248 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/22836248 |
| http://purl.uniprot.org/citations/22836248 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/22836248 |
| http://purl.uniprot.org/uniprot/#_O55042-mappedCitation-22836248 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/22836248 |
| http://purl.uniprot.org/uniprot/O55042 | http://purl.uniprot.org/core/mappedCitation | http://purl.uniprot.org/citations/22836248 |