| http://purl.uniprot.org/citations/22840776 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/22840776 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/22840776 | http://www.w3.org/2000/01/rdf-schema#comment | "Understanding how drugs work in vivo is critical for drug design and for maximizing the potential of currently available drugs. 5-nitrofurans are a class of prodrugs widely used to treat bacterial and trypanosome infections, but despite relative specificity, 5-nitrofurans often cause serious toxic side effects in people. Here, we use yeast and zebrafish, as well as human in vitro systems, to assess the biological activity of 5-nitrofurans, and we identify a conserved interaction between aldehyde dehydrogenase (ALDH) 2 and 5-nitrofurans across these species. In addition, we show that the activity of nifurtimox, a 5-nitrofuran anti-trypanosome prodrug, is dependent on zebrafish Aldh2 and is a substrate for human ALDH2. This study reveals a conserved and biologically relevant ALDH2-5-nitrofuran interaction that may have important implications for managing the toxicity of 5-nitrofuran treatment."xsd:string |
| http://purl.uniprot.org/citations/22840776 | http://purl.org/dc/terms/identifier | "doi:10.1016/j.chembiol.2012.05.017"xsd:string |
| http://purl.uniprot.org/citations/22840776 | http://purl.uniprot.org/core/author | "Johnson S.L."xsd:string |
| http://purl.uniprot.org/citations/22840776 | http://purl.uniprot.org/core/author | "Johnson S.L."xsd:string |
| http://purl.uniprot.org/citations/22840776 | http://purl.uniprot.org/core/author | "Taylor K.L."xsd:string |
| http://purl.uniprot.org/citations/22840776 | http://purl.uniprot.org/core/author | "Taylor K.L."xsd:string |
| http://purl.uniprot.org/citations/22840776 | http://purl.uniprot.org/core/author | "Zhou L."xsd:string |
| http://purl.uniprot.org/citations/22840776 | http://purl.uniprot.org/core/author | "Zhou L."xsd:string |
| http://purl.uniprot.org/citations/22840776 | http://purl.uniprot.org/core/author | "Smith T.K."xsd:string |
| http://purl.uniprot.org/citations/22840776 | http://purl.uniprot.org/core/author | "Smith T.K."xsd:string |
| http://purl.uniprot.org/citations/22840776 | http://purl.uniprot.org/core/author | "Melton D.W."xsd:string |
| http://purl.uniprot.org/citations/22840776 | http://purl.uniprot.org/core/author | "Melton D.W."xsd:string |
| http://purl.uniprot.org/citations/22840776 | http://purl.uniprot.org/core/author | "Zeng Z."xsd:string |
| http://purl.uniprot.org/citations/22840776 | http://purl.uniprot.org/core/author | "Zeng Z."xsd:string |
| http://purl.uniprot.org/citations/22840776 | http://purl.uniprot.org/core/author | "Ishizaki H."xsd:string |
| http://purl.uniprot.org/citations/22840776 | http://purl.uniprot.org/core/author | "Ishizaki H."xsd:string |
| http://purl.uniprot.org/citations/22840776 | http://purl.uniprot.org/core/author | "Westwood N.J."xsd:string |
| http://purl.uniprot.org/citations/22840776 | http://purl.uniprot.org/core/author | "Westwood N.J."xsd:string |
| http://purl.uniprot.org/citations/22840776 | http://purl.uniprot.org/core/author | "Tyers M."xsd:string |
| http://purl.uniprot.org/citations/22840776 | http://purl.uniprot.org/core/author | "Tyers M."xsd:string |
| http://purl.uniprot.org/citations/22840776 | http://purl.uniprot.org/core/author | "Mitchell A."xsd:string |
| http://purl.uniprot.org/citations/22840776 | http://purl.uniprot.org/core/author | "Mitchell A."xsd:string |
| http://purl.uniprot.org/citations/22840776 | http://purl.uniprot.org/core/author | "Patton E.E."xsd:string |