| http://purl.uniprot.org/citations/22840842 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/22840842 | http://www.w3.org/2000/01/rdf-schema#comment | "Yersinia pestis, the causative agent of plague, is able to suppress production of inflammatory cytokines IL-18 and IL-1β, which are generated through caspase-1-activating nucleotide-binding domain and leucine-rich repeat (NLR)-containing inflammasomes. Here, we sought to elucidate the role of NLRs and IL-18 during plague. Lack of IL-18 signaling led to increased susceptibility to Y. pestis, producing tetra-acylated lipid A, and an attenuated strain producing a Y. pseudotuberculosis-like hexa-acylated lipid A. We found that the NLRP12 inflammasome was an important regulator controlling IL-18 and IL-1β production after Y. pestis infection, and NLRP12-deficient mice were more susceptible to bacterial challenge. NLRP12 also directed interferon-γ production via induction of IL-18, but had minimal effect on signaling to the transcription factor NF-κB. These studies reveal a role for NLRP12 in host resistance against pathogens. Minimizing NLRP12 inflammasome activation may have been a central factor in evolution of the high virulence of Y. pestis."xsd:string |
| http://purl.uniprot.org/citations/22840842 | http://purl.org/dc/terms/identifier | "doi:10.1016/j.immuni.2012.07.006"xsd:string |
| http://purl.uniprot.org/citations/22840842 | http://purl.uniprot.org/core/author | "Liu Q."xsd:string |
| http://purl.uniprot.org/citations/22840842 | http://purl.uniprot.org/core/author | "Bertin J."xsd:string |
| http://purl.uniprot.org/citations/22840842 | http://purl.uniprot.org/core/author | "Reed G."xsd:string |
| http://purl.uniprot.org/citations/22840842 | http://purl.uniprot.org/core/author | "Iwakura Y."xsd:string |
| http://purl.uniprot.org/citations/22840842 | http://purl.uniprot.org/core/author | "Fitzgerald K.A."xsd:string |
| http://purl.uniprot.org/citations/22840842 | http://purl.uniprot.org/core/author | "Rathinam V.A."xsd:string |
| http://purl.uniprot.org/citations/22840842 | http://purl.uniprot.org/core/author | "Vanaja S.K."xsd:string |
| http://purl.uniprot.org/citations/22840842 | http://purl.uniprot.org/core/author | "Vladimer G.I."xsd:string |
| http://purl.uniprot.org/citations/22840842 | http://purl.uniprot.org/core/author | "Goguen J.D."xsd:string |
| http://purl.uniprot.org/citations/22840842 | http://purl.uniprot.org/core/author | "Lien E."xsd:string |
| http://purl.uniprot.org/citations/22840842 | http://purl.uniprot.org/core/author | "Weng D."xsd:string |
| http://purl.uniprot.org/citations/22840842 | http://purl.uniprot.org/core/author | "Conlon J.E."xsd:string |
| http://purl.uniprot.org/citations/22840842 | http://purl.uniprot.org/core/author | "Aune M.H."xsd:string |
| http://purl.uniprot.org/citations/22840842 | http://purl.uniprot.org/core/author | "Burbage J.J."xsd:string |
| http://purl.uniprot.org/citations/22840842 | http://purl.uniprot.org/core/author | "Mecsas J.C."xsd:string |
| http://purl.uniprot.org/citations/22840842 | http://purl.uniprot.org/core/author | "Paquette S.W."xsd:string |
| http://purl.uniprot.org/citations/22840842 | http://purl.uniprot.org/core/author | "Proulx M.K."xsd:string |
| http://purl.uniprot.org/citations/22840842 | http://purl.uniprot.org/core/date | "2012"xsd:gYear |
| http://purl.uniprot.org/citations/22840842 | http://purl.uniprot.org/core/name | "Immunity"xsd:string |
| http://purl.uniprot.org/citations/22840842 | http://purl.uniprot.org/core/pages | "96-107"xsd:string |
| http://purl.uniprot.org/citations/22840842 | http://purl.uniprot.org/core/title | "The NLRP12 inflammasome recognizes Yersinia pestis."xsd:string |
| http://purl.uniprot.org/citations/22840842 | http://purl.uniprot.org/core/volume | "37"xsd:string |