| http://purl.uniprot.org/citations/22841546 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/22841546 | http://www.w3.org/2000/01/rdf-schema#comment | "PFKFB3 is a target gene of peroxisome proliferator-activated receptor gamma (PPARγ) and encodes for inducible 6-phosphofructo-2-kinase (iPFK2). As a key regulatory enzyme that stimulates glycolysis, PFKFB3/iPFK2 links adipocyte metabolic and inflammatory responses. Additionally, PFKFB3/iPFK2 is involved in the effect of active PPARγ on suppressing overnutrition-induced adipose tissue inflammatory response, which accounts for the insulin-sensitizing and antidiabetic effects of PPARγ activation. Using PFKFB3/iPFK2-disrupted mice, the present study investigated the role of PFKFB3/iPFK2 in regulating overnutrition-associated intestine inflammatory response and in mediating the effects of PPARγ activation. In wild-type mice, intestine PFKFB3/iPFK2 was increased in response to high-fat diet (HFD) feeding compared with that in mice fed a low-fat diet. However, intestine PFKFB3/iPFK2 was decreased in PFKFB3/iPFK2-disrupted mice and did not respond to HFD feeding. Furthermore, on an HFD, PFKFB3/iPFK2-disrupted mice displayed a significant increase in major intestine proinflammatory indicators such as toll-like receptor 4 expression, c-Jun N-terminal kinase 1 and nuclear factor kappa B phosphorylation, and proinflammatory cytokine expression compared with wild-type littermates. Upon treatment with rosiglitazone, an agonist of PPARγ, intestine proinflammatory indicators were markedly decreased in wild-type mice, but to a much lesser degree in PFKFB3/iPFK2-disrupted mice. Overall, the status of HFD-induced intestine inflammatory response in all treated mice correlated inversely with systemic insulin sensitivity, indicated by the homeostasis model assessment of insulin resistance data. Together, these results suggest that PFKFB3/iPFK2 is critically involved in the effect of PPARγ activation on suppressing diet-induced intestine inflammatory response."xsd:string |
| http://purl.uniprot.org/citations/22841546 | http://purl.org/dc/terms/identifier | "doi:10.1016/j.jnutbio.2012.04.007"xsd:string |
| http://purl.uniprot.org/citations/22841546 | http://purl.uniprot.org/core/author | "Guo X."xsd:string |
| http://purl.uniprot.org/citations/22841546 | http://purl.uniprot.org/core/author | "Li H."xsd:string |
| http://purl.uniprot.org/citations/22841546 | http://purl.uniprot.org/core/author | "Xu H."xsd:string |
| http://purl.uniprot.org/citations/22841546 | http://purl.uniprot.org/core/author | "Wu C."xsd:string |
| http://purl.uniprot.org/citations/22841546 | http://purl.uniprot.org/core/author | "Huo Y."xsd:string |
| http://purl.uniprot.org/citations/22841546 | http://purl.uniprot.org/core/author | "Woo S.L."xsd:string |
| http://purl.uniprot.org/citations/22841546 | http://purl.uniprot.org/core/author | "Chen Y.E."xsd:string |
| http://purl.uniprot.org/citations/22841546 | http://purl.uniprot.org/core/author | "Sturino J.M."xsd:string |
| http://purl.uniprot.org/citations/22841546 | http://purl.uniprot.org/core/author | "Thomas L.N."xsd:string |
| http://purl.uniprot.org/citations/22841546 | http://purl.uniprot.org/core/author | "Halim V."xsd:string |
| http://purl.uniprot.org/citations/22841546 | http://purl.uniprot.org/core/date | "2013"xsd:gYear |
| http://purl.uniprot.org/citations/22841546 | http://purl.uniprot.org/core/name | "J Nutr Biochem"xsd:string |
| http://purl.uniprot.org/citations/22841546 | http://purl.uniprot.org/core/pages | "770-775"xsd:string |
| http://purl.uniprot.org/citations/22841546 | http://purl.uniprot.org/core/title | "Disruption of inducible 6-phosphofructo-2-kinase impairs the suppressive effect of PPARgamma activation on diet-induced intestine inflammatory response."xsd:string |
| http://purl.uniprot.org/citations/22841546 | http://purl.uniprot.org/core/volume | "24"xsd:string |
| http://purl.uniprot.org/citations/22841546 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/22841546 |
| http://purl.uniprot.org/citations/22841546 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/22841546 |
| http://purl.uniprot.org/uniprot/#_A0A0A6YY64-mappedCitation-22841546 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/22841546 |
| http://purl.uniprot.org/uniprot/#_A0N0C8-mappedCitation-22841546 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/22841546 |
| http://purl.uniprot.org/uniprot/#_A0N0D0-mappedCitation-22841546 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/22841546 |
| http://purl.uniprot.org/uniprot/#_A2AUP1-mappedCitation-22841546 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/22841546 |
| http://purl.uniprot.org/uniprot/#_A2AUP5-mappedCitation-22841546 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/22841546 |