| http://purl.uniprot.org/citations/22842344 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/22842344 | http://www.w3.org/2000/01/rdf-schema#comment | "The mechanisms that regulate the T(H)9 subset of helper T cells and diseases mediated by T(H)9 cells remain poorly defined. Here we found that the costimulatory receptor OX40 was a powerful inducer of T(H)9 cells in vitro and T(H)9 cell-dependent airway inflammation in vivo. In polarizing conditions based on transforming growth factor-β (TGF-β), ligation of OX40 inhibited the production of induced regulatory T cells and the T(H)17 subset of helper T cells and diverted CD4(+)Foxp3(-) T cells to a T(H)9 phenotype. Mechanistically, OX40 activated the ubiquitin ligase TRAF6, which triggered induction of the kinase NIK in CD4(+) T cells and the noncanonical transcription factor NF-κB pathway; this subsequently led to the generation of T(H)9 cells. Thus, our study identifies a previously unknown mechanism for the induction of T(H)9 cells and may have important clinical implications in allergic inflammation."xsd:string |
| http://purl.uniprot.org/citations/22842344 | http://purl.org/dc/terms/identifier | "doi:10.1038/ni.2390"xsd:string |
| http://purl.uniprot.org/citations/22842344 | http://purl.uniprot.org/core/author | "Liu W."xsd:string |
| http://purl.uniprot.org/citations/22842344 | http://purl.uniprot.org/core/author | "Wang H."xsd:string |
| http://purl.uniprot.org/citations/22842344 | http://purl.uniprot.org/core/author | "Xiao X."xsd:string |
| http://purl.uniprot.org/citations/22842344 | http://purl.uniprot.org/core/author | "Choi Y."xsd:string |
| http://purl.uniprot.org/citations/22842344 | http://purl.uniprot.org/core/author | "Li X.C."xsd:string |
| http://purl.uniprot.org/citations/22842344 | http://purl.uniprot.org/core/author | "Chu X."xsd:string |
| http://purl.uniprot.org/citations/22842344 | http://purl.uniprot.org/core/author | "Balasubramanian S."xsd:string |
| http://purl.uniprot.org/citations/22842344 | http://purl.uniprot.org/core/author | "Walsh M.C."xsd:string |
| http://purl.uniprot.org/citations/22842344 | http://purl.uniprot.org/core/author | "Taparowsky E.J."xsd:string |
| http://purl.uniprot.org/citations/22842344 | http://purl.uniprot.org/core/author | "Fu Y.X."xsd:string |
| http://purl.uniprot.org/citations/22842344 | http://purl.uniprot.org/core/date | "2012"xsd:gYear |
| http://purl.uniprot.org/citations/22842344 | http://purl.uniprot.org/core/name | "Nat Immunol"xsd:string |
| http://purl.uniprot.org/citations/22842344 | http://purl.uniprot.org/core/pages | "981-990"xsd:string |
| http://purl.uniprot.org/citations/22842344 | http://purl.uniprot.org/core/title | "OX40 signaling favors the induction of T(H)9 cells and airway inflammation."xsd:string |
| http://purl.uniprot.org/citations/22842344 | http://purl.uniprot.org/core/volume | "13"xsd:string |
| http://purl.uniprot.org/citations/22842344 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/22842344 |
| http://purl.uniprot.org/citations/22842344 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/22842344 |
| http://purl.uniprot.org/uniprot/#_E9QAI9-mappedCitation-22842344 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/22842344 |
| http://purl.uniprot.org/uniprot/#_E9Q6W1-mappedCitation-22842344 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/22842344 |
| http://purl.uniprot.org/uniprot/#_A0A3Q4EC35-mappedCitation-22842344 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/22842344 |
| http://purl.uniprot.org/uniprot/#_A0A3Q4EC46-mappedCitation-22842344 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/22842344 |
| http://purl.uniprot.org/uniprot/#_A0A494B9Y5-mappedCitation-22842344 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/22842344 |