| http://purl.uniprot.org/citations/22859298 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/22859298 | http://www.w3.org/2000/01/rdf-schema#comment | "Excessive alcohol consumption is associated with most cases of chronic pancreatitis, a progressive necrotizing inflammatory disease that can result in pancreatic insufficiency due to acinar atrophy and fibrosis and an increased risk of pancreatic cancer. At a cellular level acute alcohol exposure can sensitize pancreatic acinar cells to secretagogue stimulation, resulting in dysregulation of intracellular Ca(2+) homeostasis and premature digestive enzyme activation; however, the molecular mechanisms by which ethanol exerts these toxic effects have remained undefined. In this study we identify Raf-1 kinase inhibitory protein as an essential mediator of ethanol-induced sensitization of cholecystokinin- and carbachol-regulated Ca(2+) signaling in pancreatic acinar cells. We show that exposure of rodent acinar cells to ethanol induces protein kinase C-dependent Raf-1 kinase inhibitory protein phosphorylation, sensitization of cholecystokinin-stimulated Ca(2+) signaling, and potentiation of both basal and cholecystokinin-stimulated extracellular signal-regulated kinase activation. Furthermore, we show that either suppression of Raf-1 kinase inhibitory protein expression using short hairpin RNA or gene ablation prevented the sensitizing effects of ethanol on cholecystokinin- and carbachol-stimulated Ca(2+) signaling and intracellular chymotrypsin activation in pancreatic acinar cells, suggesting that the modulation of Raf-1 inhibitory protein expression may have future therapeutic utility in the prevention or treatment of alcohol-associated pancreatitis."xsd:string |
| http://purl.uniprot.org/citations/22859298 | http://purl.org/dc/terms/identifier | "doi:10.1074/jbc.m112.367656"xsd:string |
| http://purl.uniprot.org/citations/22859298 | http://purl.uniprot.org/core/author | "Wang X."xsd:string |
| http://purl.uniprot.org/citations/22859298 | http://purl.uniprot.org/core/author | "Davey R.A."xsd:string |
| http://purl.uniprot.org/citations/22859298 | http://purl.uniprot.org/core/author | "Kim S.O."xsd:string |
| http://purl.uniprot.org/citations/22859298 | http://purl.uniprot.org/core/author | "Chao C."xsd:string |
| http://purl.uniprot.org/citations/22859298 | http://purl.uniprot.org/core/author | "Hellmich M.R."xsd:string |
| http://purl.uniprot.org/citations/22859298 | http://purl.uniprot.org/core/author | "Ives K.L."xsd:string |
| http://purl.uniprot.org/citations/22859298 | http://purl.uniprot.org/core/date | "2012"xsd:gYear |
| http://purl.uniprot.org/citations/22859298 | http://purl.uniprot.org/core/name | "J Biol Chem"xsd:string |
| http://purl.uniprot.org/citations/22859298 | http://purl.uniprot.org/core/pages | "33377-33388"xsd:string |
| http://purl.uniprot.org/citations/22859298 | http://purl.uniprot.org/core/title | "Raf-1 kinase inhibitory protein (RKIP) mediates ethanol-induced sensitization of secretagogue signaling in pancreatic acinar cells."xsd:string |
| http://purl.uniprot.org/citations/22859298 | http://purl.uniprot.org/core/volume | "287"xsd:string |
| http://purl.uniprot.org/citations/22859298 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/22859298 |
| http://purl.uniprot.org/citations/22859298 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/22859298 |
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