| http://purl.uniprot.org/citations/22859735 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/22859735 | http://www.w3.org/2000/01/rdf-schema#comment | "T-cell factor (Tcf)/lymphoid-enhancer factor (Lef) proteins are a structurally diverse family of deoxyribonucleic acid-binding proteins that have essential nuclear functions in Wnt/β-catenin signalling. Expression of Wnt/β-catenin target genes is highly dependent on context, but the precise role of Tcf/Lef family members in the generation and maintenance of cell-type-specific Wnt/β-catenin responses is unknown. Herein, we show that induction of a subset of Wnt/β-catenin targets in embryonic stem cells depends on Tcf1 and Tcf4, whereas other co-expressed Tcf/Lef family members cannot induce these targets. The Tcf1/Tcf4-dependent gene responses to Wnt are primarily if not exclusively mediated by C-clamp-containing Tcf1E and Tcf4E splice variants. A combined knockdown of Tcf1/Tcf4 abrogates Wnt-inducible transcription but does not affect the active chromatin conformation of their targets. Thus, the transcriptionally poised state of Wnt/β-catenin targets is maintained independent of Tcf/Lef proteins. Conversely, ectopically overexpressed Tcf1E cannot invade silent chromatin and fails to initiate expression of inactive Wnt/β-catenin targets even if repressive chromatin modifications are abolished. The observed non-redundant functions of Tcf1/Tcf4 isoforms in acute transcriptional activation demonstrated that the cell-type-specific complement of Tcf/Lef proteins is a critical determinant of context-dependent Wnt/β-catenin responses. Moreover, the apparent inability to cope with chromatin uncovers an intrinsic property of Tcf/Lef proteins that prevents false ectopic induction and ensures spatiotemporal stability of Wnt/β-catenin target gene expression."xsd:string |
| http://purl.uniprot.org/citations/22859735 | http://purl.org/dc/terms/identifier | "doi:10.1093/nar/gks690"xsd:string |
| http://purl.uniprot.org/citations/22859735 | http://purl.uniprot.org/core/author | "Hecht A."xsd:string |
| http://purl.uniprot.org/citations/22859735 | http://purl.uniprot.org/core/author | "Wallmen B."xsd:string |
| http://purl.uniprot.org/citations/22859735 | http://purl.uniprot.org/core/author | "Schrempp M."xsd:string |
| http://purl.uniprot.org/citations/22859735 | http://purl.uniprot.org/core/date | "2012"xsd:gYear |
| http://purl.uniprot.org/citations/22859735 | http://purl.uniprot.org/core/name | "Nucleic Acids Res"xsd:string |
| http://purl.uniprot.org/citations/22859735 | http://purl.uniprot.org/core/pages | "9455-9469"xsd:string |
| http://purl.uniprot.org/citations/22859735 | http://purl.uniprot.org/core/title | "Intrinsic properties of Tcf1 and Tcf4 splice variants determine cell-type-specific Wnt/beta-catenin target gene expression."xsd:string |
| http://purl.uniprot.org/citations/22859735 | http://purl.uniprot.org/core/volume | "40"xsd:string |
| http://purl.uniprot.org/citations/22859735 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/22859735 |
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| http://purl.uniprot.org/uniprot/#_A0A0J9YUK1-mappedCitation-22859735 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/22859735 |