| http://purl.uniprot.org/citations/22860893 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/22860893 | http://www.w3.org/2000/01/rdf-schema#comment | "Interleukin (IL)-24 has death-promoting effects on various proliferating cells including B-cells from chronic lymphocytic leukemia (CLL) and germinal center B-cells, but its molecular mechanisms are poorly understood. Using a B-cell differentiation model and mRNA profiling, we found that recombinant (r)IL-24 stimulated genes of the mitochondrial apoptotic pathway (Bax, Bid, Casp8, COX6C, COX7B) after 36 h, whereas the transcription of genes involved in DNA replication and metabolism was inhibited within 6 h. Unexpectedly, insulin-like growth factor 1 (IGF1), a hormone known to promote cell growth, was stimulated by IL-24. Activated B-cells express receptor for IGF1, to which they become sensitized and undergo apoptosis, a mechanism similar in this respect to IL-24-induced cell death. Furthermore, inhibition of the IGF1 pathway reversed the effects of IL-24. IL-24-mediated apoptosis was also antagonized by pifithrin-alpha, an inhibitor of p53 transactivation. Altogether, these results disclose sequential molecular signals generated by IL-24 in activated B-cells."xsd:string |
| http://purl.uniprot.org/citations/22860893 | http://purl.org/dc/terms/identifier | "doi:10.3109/10428194.2012.717079"xsd:string |
| http://purl.uniprot.org/citations/22860893 | http://purl.uniprot.org/core/author | "Perrot A."xsd:string |
| http://purl.uniprot.org/citations/22860893 | http://purl.uniprot.org/core/author | "Frippiat J.P."xsd:string |
| http://purl.uniprot.org/citations/22860893 | http://purl.uniprot.org/core/author | "Nemos C."xsd:string |
| http://purl.uniprot.org/citations/22860893 | http://purl.uniprot.org/core/author | "Dalloul A."xsd:string |
| http://purl.uniprot.org/citations/22860893 | http://purl.uniprot.org/core/author | "Hadife N."xsd:string |
| http://purl.uniprot.org/citations/22860893 | http://purl.uniprot.org/core/author | "Hamade T."xsd:string |
| http://purl.uniprot.org/citations/22860893 | http://purl.uniprot.org/core/date | "2013"xsd:gYear |
| http://purl.uniprot.org/citations/22860893 | http://purl.uniprot.org/core/name | "Leuk Lymphoma"xsd:string |
| http://purl.uniprot.org/citations/22860893 | http://purl.uniprot.org/core/pages | "587-597"xsd:string |
| http://purl.uniprot.org/citations/22860893 | http://purl.uniprot.org/core/title | "Interleukin-24 mediates apoptosis in human B-cells through early activation of cell cycle arrest followed by late induction of the mitochondrial apoptosis pathway."xsd:string |
| http://purl.uniprot.org/citations/22860893 | http://purl.uniprot.org/core/volume | "54"xsd:string |
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