| http://purl.uniprot.org/citations/22862561 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/22862561 | http://www.w3.org/2000/01/rdf-schema#comment | "Apolipoprotein E (APOE) genotype affects outcomes of Alzheimer's disease and other conditions of brain damage. Using APOE knock-in mice, we have previously shown that APOE-ε4 Targeted Replacement (TR) mice have fewer dendritic spines and reduced branching in cortical neurons. As dendritic spines are post-synaptic sites of excitatory neurotransmission, we used APOE TR mice to examine whether APOE genotype affected the various elements of the glutamate-glutamine cycle. We found that levels of glutamine synthetase and glutamate uptake transporters were unchanged among the APOE genotypes. However, compared with APOE-ε3 TR mice, APOE-ε4 TR mice had decreased glutaminase levels (18%, p < 0.05), suggesting decreased conversion of glutamine to glutamate. APOE-ε4 TR mice also had increased levels of the vesicular glutamate transporter 1 (20%, p < 0.05), suggesting that APOE genotype affects pre-synaptic terminal composition. To address whether these changes affected normal neurotransmission, we examined the production and metabolism of glutamate and glutamine at 4-5 months and 1 year. Using high-frequency (13)C/(1)H nuclear magnetic resonance spectroscopy, we found that APOE-ε4 TR mice have decreased production of glutamate and increased levels of glutamine. These factors may contribute to the increased risk of neurodegeneration associated with APOE-ε4, and also act as surrogate markers for Alzheimer's disease risk."xsd:string |
| http://purl.uniprot.org/citations/22862561 | http://purl.org/dc/terms/identifier | "doi:10.1111/j.1471-4159.2012.07908.x"xsd:string |
| http://purl.uniprot.org/citations/22862561 | http://purl.uniprot.org/core/author | "Rebeck G.W."xsd:string |
| http://purl.uniprot.org/citations/22862561 | http://purl.uniprot.org/core/author | "Moussa C.E."xsd:string |
| http://purl.uniprot.org/citations/22862561 | http://purl.uniprot.org/core/author | "Dumanis S.B."xsd:string |
| http://purl.uniprot.org/citations/22862561 | http://purl.uniprot.org/core/author | "DiBattista A.M."xsd:string |
| http://purl.uniprot.org/citations/22862561 | http://purl.uniprot.org/core/author | "Miessau M."xsd:string |
| http://purl.uniprot.org/citations/22862561 | http://purl.uniprot.org/core/date | "2013"xsd:gYear |
| http://purl.uniprot.org/citations/22862561 | http://purl.uniprot.org/core/name | "J Neurochem"xsd:string |
| http://purl.uniprot.org/citations/22862561 | http://purl.uniprot.org/core/pages | "4-14"xsd:string |
| http://purl.uniprot.org/citations/22862561 | http://purl.uniprot.org/core/title | "APOE genotype affects the pre-synaptic compartment of glutamatergic nerve terminals."xsd:string |
| http://purl.uniprot.org/citations/22862561 | http://purl.uniprot.org/core/volume | "124"xsd:string |
| http://purl.uniprot.org/citations/22862561 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/22862561 |
| http://purl.uniprot.org/citations/22862561 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/22862561 |
| http://purl.uniprot.org/uniprot/#_A0A1B0GX15-mappedCitation-22862561 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/22862561 |
| http://purl.uniprot.org/uniprot/#_A0A0S2Z3B1-mappedCitation-22862561 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/22862561 |
| http://purl.uniprot.org/uniprot/#_A0A0S2Z3V0-mappedCitation-22862561 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/22862561 |
| http://purl.uniprot.org/uniprot/#_A0A0S2Z3D5-mappedCitation-22862561 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/22862561 |
| http://purl.uniprot.org/uniprot/#_A0A0S2Z3J5-mappedCitation-22862561 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/22862561 |
| http://purl.uniprot.org/uniprot/#_A0A346DBY2-mappedCitation-22862561 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/22862561 |
| http://purl.uniprot.org/uniprot/#_D9ZB55-mappedCitation-22862561 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/22862561 |
| http://purl.uniprot.org/uniprot/#_G3UWN5-mappedCitation-22862561 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/22862561 |
| http://purl.uniprot.org/uniprot/#_G3UWW2-mappedCitation-22862561 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/22862561 |
| http://purl.uniprot.org/uniprot/#_G3UZM8-mappedCitation-22862561 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/22862561 |