| http://purl.uniprot.org/citations/22863011 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/22863011 | http://www.w3.org/2000/01/rdf-schema#comment | "Endothelium in embryonic hematopoietic tissues generates hematopoietic stem/progenitor cells; however, it is unknown how its unique potential is specified. We show that transcription factor Scl/Tal1 is essential for both establishing the hematopoietic transcriptional program in hemogenic endothelium and preventing its misspecification to a cardiomyogenic fate. Scl(-/-) embryos activated a cardiac transcriptional program in yolk sac endothelium, leading to the emergence of CD31+Pdgfrα+ cardiogenic precursors that generated spontaneously beating cardiomyocytes. Ectopic cardiogenesis was also observed in Scl(-/-) hearts, where the disorganized endocardium precociously differentiated into cardiomyocytes. Induction of mosaic deletion of Scl in Scl(fl/fl)Rosa26Cre-ER(T2) embryos revealed a cell-intrinsic, temporal requirement for Scl to prevent cardiomyogenesis from endothelium. Scl(-/-) endothelium also upregulated the expression of Wnt antagonists, which promoted rapid cardiomyocyte differentiation of ectopic cardiogenic cells. These results reveal unexpected plasticity in embryonic endothelium such that loss of a single master regulator can induce ectopic cardiomyogenesis from endothelial cells."xsd:string |
| http://purl.uniprot.org/citations/22863011 | http://purl.org/dc/terms/identifier | "doi:10.1016/j.cell.2012.06.026"xsd:string |
| http://purl.uniprot.org/citations/22863011 | http://purl.uniprot.org/core/author | "Li X."xsd:string |
| http://purl.uniprot.org/citations/22863011 | http://purl.uniprot.org/core/author | "Nakano H."xsd:string |
| http://purl.uniprot.org/citations/22863011 | http://purl.uniprot.org/core/author | "Wang Y."xsd:string |
| http://purl.uniprot.org/citations/22863011 | http://purl.uniprot.org/core/author | "Zhou J."xsd:string |
| http://purl.uniprot.org/citations/22863011 | http://purl.uniprot.org/core/author | "Nakano A."xsd:string |
| http://purl.uniprot.org/citations/22863011 | http://purl.uniprot.org/core/author | "Mikkola H.K."xsd:string |
| http://purl.uniprot.org/citations/22863011 | http://purl.uniprot.org/core/author | "Orkin S.H."xsd:string |
| http://purl.uniprot.org/citations/22863011 | http://purl.uniprot.org/core/author | "Pellegrini M."xsd:string |
| http://purl.uniprot.org/citations/22863011 | http://purl.uniprot.org/core/author | "Kurdistani S.K."xsd:string |
| http://purl.uniprot.org/citations/22863011 | http://purl.uniprot.org/core/author | "Org T."xsd:string |
| http://purl.uniprot.org/citations/22863011 | http://purl.uniprot.org/core/author | "Sasidharan R."xsd:string |
| http://purl.uniprot.org/citations/22863011 | http://purl.uniprot.org/core/author | "Chen J.N."xsd:string |
| http://purl.uniprot.org/citations/22863011 | http://purl.uniprot.org/core/author | "Evans S.M."xsd:string |
| http://purl.uniprot.org/citations/22863011 | http://purl.uniprot.org/core/author | "Hunter S."xsd:string |
| http://purl.uniprot.org/citations/22863011 | http://purl.uniprot.org/core/author | "Ferrari R."xsd:string |
| http://purl.uniprot.org/citations/22863011 | http://purl.uniprot.org/core/author | "Schredelseker J."xsd:string |
| http://purl.uniprot.org/citations/22863011 | http://purl.uniprot.org/core/author | "Montel-Hagen A."xsd:string |
| http://purl.uniprot.org/citations/22863011 | http://purl.uniprot.org/core/author | "Boogerd C.J."xsd:string |
| http://purl.uniprot.org/citations/22863011 | http://purl.uniprot.org/core/author | "Van Handel B."xsd:string |
| http://purl.uniprot.org/citations/22863011 | http://purl.uniprot.org/core/date | "2012"xsd:gYear |
| http://purl.uniprot.org/citations/22863011 | http://purl.uniprot.org/core/name | "Cell"xsd:string |
| http://purl.uniprot.org/citations/22863011 | http://purl.uniprot.org/core/pages | "590-605"xsd:string |