| http://purl.uniprot.org/citations/22864612 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/22864612 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/22864612 | http://www.w3.org/2000/01/rdf-schema#comment | "Synapse formation and maturation requires bidirectional communication across the synaptic cleft. The trans-synaptic Neurexin-Neuroligin complex can bridge this cleft, and severe synapse assembly deficits are found in Drosophila melanogaster neuroligin (Nlg1, dnlg1) and neurexin (Nrx-1, dnrx) mutants. We show that the presynaptic active zone protein Syd-1 interacts with Nrx-1 to control synapse formation at the Drosophila neuromuscular junction. Mutants in Syd-1 (RhoGAP100F, dsyd-1), Nrx-1 and Nlg1 shared active zone cytomatrix defects, which were nonadditive. Syd-1 and Nrx-1 formed a complex in vivo, and Syd-1 was important for synaptic clustering and immobilization of Nrx-1. Consequently, postsynaptic clustering of Nlg1 was affected in Syd-1 mutants, and in vivo glutamate receptor incorporation was changed in Syd-1, Nrx-1 and Nlg1 mutants. Stabilization of nascent Syd-1-Liprin-α (DLiprin-α) clusters, important to initialize active zone formation, was Nlg1 dependent. Thus, cooperation between Syd-1 and Nrx-1-Nlg1 seems to orchestrate early assembly processes between pre- and postsynaptic membranes, promoting avidity of newly forming synaptic scaffolds."xsd:string |
| http://purl.uniprot.org/citations/22864612 | http://purl.org/dc/terms/identifier | "doi:10.1038/nn.3183"xsd:string |
| http://purl.uniprot.org/citations/22864612 | http://purl.org/dc/terms/identifier | "doi:10.1038/nn.3183"xsd:string |
| http://purl.uniprot.org/citations/22864612 | http://purl.uniprot.org/core/author | "Holt M."xsd:string |
| http://purl.uniprot.org/citations/22864612 | http://purl.uniprot.org/core/author | "Holt M."xsd:string |
| http://purl.uniprot.org/citations/22864612 | http://purl.uniprot.org/core/author | "Sigrist S.J."xsd:string |
| http://purl.uniprot.org/citations/22864612 | http://purl.uniprot.org/core/author | "Sigrist S.J."xsd:string |
| http://purl.uniprot.org/citations/22864612 | http://purl.uniprot.org/core/author | "Reynolds E."xsd:string |
| http://purl.uniprot.org/citations/22864612 | http://purl.uniprot.org/core/author | "Reynolds E."xsd:string |
| http://purl.uniprot.org/citations/22864612 | http://purl.uniprot.org/core/author | "Eimer S."xsd:string |
| http://purl.uniprot.org/citations/22864612 | http://purl.uniprot.org/core/author | "Eimer S."xsd:string |
| http://purl.uniprot.org/citations/22864612 | http://purl.uniprot.org/core/author | "Gupta V.K."xsd:string |
| http://purl.uniprot.org/citations/22864612 | http://purl.uniprot.org/core/author | "Gupta V.K."xsd:string |
| http://purl.uniprot.org/citations/22864612 | http://purl.uniprot.org/core/author | "Aberle H."xsd:string |
| http://purl.uniprot.org/citations/22864612 | http://purl.uniprot.org/core/author | "Aberle H."xsd:string |
| http://purl.uniprot.org/citations/22864612 | http://purl.uniprot.org/core/author | "Banovic D."xsd:string |
| http://purl.uniprot.org/citations/22864612 | http://purl.uniprot.org/core/author | "Banovic D."xsd:string |
| http://purl.uniprot.org/citations/22864612 | http://purl.uniprot.org/core/author | "Depner H."xsd:string |
| http://purl.uniprot.org/citations/22864612 | http://purl.uniprot.org/core/author | "Depner H."xsd:string |
| http://purl.uniprot.org/citations/22864612 | http://purl.uniprot.org/core/author | "Fouquet W."xsd:string |
| http://purl.uniprot.org/citations/22864612 | http://purl.uniprot.org/core/author | "Fouquet W."xsd:string |
| http://purl.uniprot.org/citations/22864612 | http://purl.uniprot.org/core/author | "Khorramshahi O."xsd:string |
| http://purl.uniprot.org/citations/22864612 | http://purl.uniprot.org/core/author | "Khorramshahi O."xsd:string |