| http://purl.uniprot.org/citations/22869143 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/22869143 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/22869143 | http://www.w3.org/2000/01/rdf-schema#comment | "Promyelocytic leukemia protein (PML) modulates the p53 tumor suppressor through its interaction with p53 and MDM2. We found that activated big MAP kinase 1 (BMK1) preferentially associates with PML isoform IV and disrupts PML-MDM2 interaction. Doxorubicin, a common chemotherapeutic agent, is known to promote PML-mediated p53 activation in part by promoting PML-dependent MDM2 nucleolar sequestration. We discovered that BMK1 deactivation coupled with doxorubicin synergistically enhanced MDM2 nucleolar sequestration and, consequently, promoted PML-mediated p53 upregulation leading to tumor cell apoptosis in vitro and tumor regression in vivo. Collectively, these results not only suggest that BMK1 activity has a role in suppressing p53 by blocking the interaction between PML and MDM2, but also implicate that pharmacological BMK1 inhibitor should significantly enhance the anticancer capacity of doxorubicin-based chemotherapy."xsd:string |
| http://purl.uniprot.org/citations/22869143 | http://purl.org/dc/terms/identifier | "doi:10.1038/onc.2012.332"xsd:string |
| http://purl.uniprot.org/citations/22869143 | http://purl.org/dc/terms/identifier | "doi:10.1038/onc.2012.332"xsd:string |
| http://purl.uniprot.org/citations/22869143 | http://purl.uniprot.org/core/author | "Chen R."xsd:string |
| http://purl.uniprot.org/citations/22869143 | http://purl.uniprot.org/core/author | "Chen R."xsd:string |
| http://purl.uniprot.org/citations/22869143 | http://purl.uniprot.org/core/author | "Deng X."xsd:string |
| http://purl.uniprot.org/citations/22869143 | http://purl.uniprot.org/core/author | "Deng X."xsd:string |
| http://purl.uniprot.org/citations/22869143 | http://purl.uniprot.org/core/author | "Yang Q."xsd:string |
| http://purl.uniprot.org/citations/22869143 | http://purl.uniprot.org/core/author | "Yang Q."xsd:string |
| http://purl.uniprot.org/citations/22869143 | http://purl.uniprot.org/core/author | "Yates J.R. III"xsd:string |
| http://purl.uniprot.org/citations/22869143 | http://purl.uniprot.org/core/author | "Yates J.R. III"xsd:string |
| http://purl.uniprot.org/citations/22869143 | http://purl.uniprot.org/core/author | "Liao L."xsd:string |
| http://purl.uniprot.org/citations/22869143 | http://purl.uniprot.org/core/author | "Liao L."xsd:string |
| http://purl.uniprot.org/citations/22869143 | http://purl.uniprot.org/core/author | "Gray N.S."xsd:string |
| http://purl.uniprot.org/citations/22869143 | http://purl.uniprot.org/core/author | "Gray N.S."xsd:string |
| http://purl.uniprot.org/citations/22869143 | http://purl.uniprot.org/core/author | "Lee J.D."xsd:string |
| http://purl.uniprot.org/citations/22869143 | http://purl.uniprot.org/core/author | "Lee J.D."xsd:string |
| http://purl.uniprot.org/citations/22869143 | http://purl.uniprot.org/core/date | "2013"xsd:gYear |
| http://purl.uniprot.org/citations/22869143 | http://purl.uniprot.org/core/date | "2013"xsd:gYear |
| http://purl.uniprot.org/citations/22869143 | http://purl.uniprot.org/core/name | "Oncogene"xsd:string |
| http://purl.uniprot.org/citations/22869143 | http://purl.uniprot.org/core/name | "Oncogene"xsd:string |
| http://purl.uniprot.org/citations/22869143 | http://purl.uniprot.org/core/pages | "3156-3164"xsd:string |
| http://purl.uniprot.org/citations/22869143 | http://purl.uniprot.org/core/pages | "3156-3164"xsd:string |