| http://purl.uniprot.org/citations/22870271 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/22870271 | http://www.w3.org/2000/01/rdf-schema#comment | "How do effector CD4 T cells escape cell death during the contraction of the immune response (IR) remain largely unknown. CD47, through interactions with thrombospondin-1 (TSP-1) and SIRP-α, is implicated in cell death and phagocytosis of malignant cells. Here, we reported a reduction in SIRP-α-Fc binding to effector memory T cells (T(EM)) and in vitro TCR-activated human CD4 T cells that was linked to TSP-1/CD47-induced cell death. The reduced SIRP-α-Fc binding (CD47(low) status) was not detected when CD4 T cells were stained with two anti-CD47 mAbs, which recognize distinct epitopes. In contrast, increased SIRP-α-Fc binding (CD47(high) status) marked central memory T cells (T(CM)) as well as activated CD4 T cells exposed to IL-2, and correlated with resistance to TSP-1/CD47-mediated killing. Auto-aggressive CD4 effectors, which accumulated in lymph nodes and at mucosal sites of patients with Crohn's disease, displayed a CD47(high) status despite a high level of TSP-1 release in colonic tissues. In mice, CD47 (CD47(low) status) was required on antigen (Ag)-specific CD4 effectors for the contraction of the IR in vivo, as significantly lower numbers of Ag-specific CD47(+/+)CD4 T cells were recovered when compared to Ag-specific CD47(-/-) CD4 T cells. In conclusion, we demonstrate that a transient change in the status of CD47, i.e. from CD47(high) to CD47(low), on CD4 effectors regulates the decision-making process that leads to CD47-mediated cell death and contraction of the IR while maintenance of a CD47(high) status on tissue-destructive CD4 effectors prevents the resolution of the inflammatory response."xsd:string |
| http://purl.uniprot.org/citations/22870271 | http://purl.org/dc/terms/identifier | "doi:10.1371/journal.pone.0041972"xsd:string |
| http://purl.uniprot.org/citations/22870271 | http://purl.uniprot.org/core/author | "Richard C."xsd:string |
| http://purl.uniprot.org/citations/22870271 | http://purl.uniprot.org/core/author | "Cabon L."xsd:string |
| http://purl.uniprot.org/citations/22870271 | http://purl.uniprot.org/core/author | "Rubio M."xsd:string |
| http://purl.uniprot.org/citations/22870271 | http://purl.uniprot.org/core/author | "Baba N."xsd:string |
| http://purl.uniprot.org/citations/22870271 | http://purl.uniprot.org/core/author | "Sarfati M."xsd:string |
| http://purl.uniprot.org/citations/22870271 | http://purl.uniprot.org/core/author | "Franchimont D."xsd:string |
| http://purl.uniprot.org/citations/22870271 | http://purl.uniprot.org/core/author | "Fortin G."xsd:string |
| http://purl.uniprot.org/citations/22870271 | http://purl.uniprot.org/core/author | "Torres A.C."xsd:string |
| http://purl.uniprot.org/citations/22870271 | http://purl.uniprot.org/core/author | "Wakahara K."xsd:string |
| http://purl.uniprot.org/citations/22870271 | http://purl.uniprot.org/core/author | "Soucy G."xsd:string |
| http://purl.uniprot.org/citations/22870271 | http://purl.uniprot.org/core/author | "Van V.Q."xsd:string |
| http://purl.uniprot.org/citations/22870271 | http://purl.uniprot.org/core/author | "Panzini B."xsd:string |
| http://purl.uniprot.org/citations/22870271 | http://purl.uniprot.org/core/author | "Susin S."xsd:string |
| http://purl.uniprot.org/citations/22870271 | http://purl.uniprot.org/core/date | "2012"xsd:gYear |
| http://purl.uniprot.org/citations/22870271 | http://purl.uniprot.org/core/name | "PLoS One"xsd:string |
| http://purl.uniprot.org/citations/22870271 | http://purl.uniprot.org/core/pages | "e41972"xsd:string |
| http://purl.uniprot.org/citations/22870271 | http://purl.uniprot.org/core/title | "CD47(low) status on CD4 effectors is necessary for the contraction/resolution of the immune response in humans and mice."xsd:string |
| http://purl.uniprot.org/citations/22870271 | http://purl.uniprot.org/core/volume | "7"xsd:string |
| http://purl.uniprot.org/citations/22870271 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/22870271 |
| http://purl.uniprot.org/citations/22870271 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/22870271 |
| http://purl.uniprot.org/uniprot/#_D3Z187-mappedCitation-22870271 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/22870271 |
| http://purl.uniprot.org/uniprot/#_A0A2R8VI30-mappedCitation-22870271 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/22870271 |