| http://purl.uniprot.org/citations/22871024 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/22871024 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/22871024 | http://www.w3.org/2000/01/rdf-schema#comment | "Human THEM4 (hTHEM4) is comprised of a catalytically active hotdog-fold acyl-CoA thioesterase domain and an N-terminal domain of unknown fold and function. hTHEM4 has been linked to Akt1 regulation and cell apoptosis. Herein, we report the X-ray structure of hHTEM4 bound with undecan-2-one-CoA. Structure guided mutagenesis was carried out to confirm the catalytic residues. The N-terminal domain is shown to be partially comprised of irregular and flexible secondary structure, reminiscent of a protein-binding domain. We demonstrate direct hTHEM4-Akt1 binding by immunoprecipitation and by inhibition of Akt1 kinase activity, thus providing independent evidence that hTHEM4 is an Akt1 negative regulator."xsd:string |
| http://purl.uniprot.org/citations/22871024 | http://purl.org/dc/terms/identifier | "doi:10.1021/bi300968n"xsd:string |
| http://purl.uniprot.org/citations/22871024 | http://purl.org/dc/terms/identifier | "doi:10.1021/bi300968n"xsd:string |
| http://purl.uniprot.org/citations/22871024 | http://purl.uniprot.org/core/author | "Lim K."xsd:string |
| http://purl.uniprot.org/citations/22871024 | http://purl.uniprot.org/core/author | "Lim K."xsd:string |
| http://purl.uniprot.org/citations/22871024 | http://purl.uniprot.org/core/author | "Dunaway-Mariano D."xsd:string |
| http://purl.uniprot.org/citations/22871024 | http://purl.uniprot.org/core/author | "Dunaway-Mariano D."xsd:string |
| http://purl.uniprot.org/citations/22871024 | http://purl.uniprot.org/core/author | "Luo L."xsd:string |
| http://purl.uniprot.org/citations/22871024 | http://purl.uniprot.org/core/author | "Luo L."xsd:string |
| http://purl.uniprot.org/citations/22871024 | http://purl.uniprot.org/core/author | "Zhao H."xsd:string |
| http://purl.uniprot.org/citations/22871024 | http://purl.uniprot.org/core/author | "Zhao H."xsd:string |
| http://purl.uniprot.org/citations/22871024 | http://purl.uniprot.org/core/author | "Herzberg O."xsd:string |
| http://purl.uniprot.org/citations/22871024 | http://purl.uniprot.org/core/author | "Herzberg O."xsd:string |
| http://purl.uniprot.org/citations/22871024 | http://purl.uniprot.org/core/author | "Latham J.A."xsd:string |
| http://purl.uniprot.org/citations/22871024 | http://purl.uniprot.org/core/author | "Latham J.A."xsd:string |
| http://purl.uniprot.org/citations/22871024 | http://purl.uniprot.org/core/author | "Dominguez D."xsd:string |
| http://purl.uniprot.org/citations/22871024 | http://purl.uniprot.org/core/author | "Dominguez D."xsd:string |
| http://purl.uniprot.org/citations/22871024 | http://purl.uniprot.org/core/author | "Pathak M.C."xsd:string |
| http://purl.uniprot.org/citations/22871024 | http://purl.uniprot.org/core/author | "Pathak M.C."xsd:string |
| http://purl.uniprot.org/citations/22871024 | http://purl.uniprot.org/core/author | "Choudry A."xsd:string |
| http://purl.uniprot.org/citations/22871024 | http://purl.uniprot.org/core/author | "Choudry A."xsd:string |
| http://purl.uniprot.org/citations/22871024 | http://purl.uniprot.org/core/date | "2012"xsd:gYear |
| http://purl.uniprot.org/citations/22871024 | http://purl.uniprot.org/core/date | "2012"xsd:gYear |